Antimicrobial Potential and Determination of Total Phenolic and Flavonoid Content of Aerial Part Extracts of Ajuga bracteosa Wall ex. Benth

groupview

Abstract
Pharmacognosy Communications,2018,8,3,114-118.
Published:July 2018
Type:Original Article

Antimicrobial Potential and Determination of Total Phenolic and Flavonoid Content of Aerial Part Extracts of Ajuga bracteosa Wall ex. Benth

Tabasum Ali, Amreen Naqash, Rukhsar Wadoo, Rumaisa Rashid, Ghulam Nabi Bader*

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar -190006, Jammu and Kashmir, INDIA.

Abstract:

Background: Traditionally, Ajuga bracteosa (family Lamiaceae) has been used to cure many diseases including gout, rheumatism, amenorrhea, diabetes, malaria, inflammation and cancer in different parts of the world. The antimicrobial activity of the plant has not been validated as yet. This study aims at validation of the folklore use of the plant as a broad spectrum anti-infective agent. Objective: To determine the total phenolic and flavonoid contents and to evaluate the antimicrobial activity using different bacterial and fungal strains. Materials and Methods: Total phenolic and flavonoid content was measured spectrometrically using Folin-Ciocalteau reagent and by aluminium chloride colorimetric methods respectively. Antimicrobial activity was evaluated by standard agar well and disc diffusion methods. Results: The phenolic and flavonoid contents were found highest in the methanolic extract (337.26 mg GAE/g and 213.52 mg RE/g respectively). A relationship was found between flavonoid and phenolic content with biological activity. The extracts also showed good antibacterial and antifungal activity. Salmonella typhi (MTCC 1688) was the most sensitive organism tested. Conclusion: The results demonstrate that Ajuga bracteosa contains high content of phenolics and flavonoids making it a promising candidate for further investigation and development as a natural broad spectrum antimicrobial agent.

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.