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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Acute and sub-chronic toxicity study of methanol leaf extract of Cardiospermum halicacabum L and Vitex negundo L in rats

    wadmin2By wadmin2December 12, 2014Updated:August 10, 2021No Comments2 Mins Read
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    Rajasekaran Aiyalu*, Arulkumaran Govindarajan and Arivukkarasu Ramasamy
    KMCH College of Pharmacy Kovai Estate, Kalapatti Road Coimbatore , INDIA.

    Pharmacognosy Communications,2015,5,1,39-45.
    DOI:10.5530/pc.2015.1.3
    Published:12 2014
    Type:Research Article

     ABSTRACT

    Introduction: Cardiospermum halicacabum L and Vitex negundo L are distributed throughout the plains of India and used in traditional practice for the treatment of inflammation and rheumatic disorders. The aim of this study is to evaluate acute and sub-chronic toxicity of methanol leaf extracts of Cardiospermum halicacabum (MLECH) and methanol leaf extract of Vitex negundo (MLEVN). MLECH and MLEVN were evaluated for acute and sub-chronic toxicity in mice and rats respectively. Materials and Methods: The acute oral toxicity study was carried out as per the OECD guidelines 423 and the sub-chronic toxicity was carried out as per the guidelines set by OECD 407 with slight modification. Body weight, food consumption, water consumption, hematological parameters, biochemical parameters, organ weight and histopathological analysis were carried out. Results: No sign of toxicity viz. lethargy, jerk, convulsion and mortality was observed upto 2000 mg/kg for MLECH and MLEVN in acute toxicity test. For subchronic toxicity test, single individual (400 mg/kg) and combined doses of MLECH and MLEVN (400 mg/kg each) in equal proportion not exhibited any signs of toxicity and mortality. Conclusion: In acute oral toxicity study, the oral administration of MLECH and MLEVN in mice was found to be safe up to a dose of 2000 mg/kg and in sub-chronic toxicity study no signs of toxicity observed at a dose of 400 mg/kg in rats.

    Keywords: Sub-chronic toxicity, Cardiospermum halicacabum, Vitex negundo.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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