Protective Effect of Hesperidin on Humoral and Cell-mediated Immunity in Rat Model

groupview

Abstract
Pharmacognosy Communications,2020,10,2,xx-xx.
DOI:
Published:March 2019
Type:Original Article

Protective Effect of Hesperidin on Humoral and Cell-mediated Immunity in Rat Model

Aditya Ganeshpurkar1,2,3, Ajay Saluja1,2,*

1Faculty of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, INDIA.

2Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.

3CVM’s A.R. College of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, INDIA.

Abstract:

Context: Hesperidin, an important bioflavonoid, is abundantly found in various foodstuffs and can be regarded as an essential nutraceutical. Hesperidin has been acknowledged for its protective and beneficial effects on various aspects of biological system. Objectives: The present study was aimed to examine the effect of hesperidin on the regulation of the immune response in experimental animal models. Materials and Methods: The immunomodulatory effects of hesperidin were determined in rats using different experimental models including carbon clearance test, cyclophosphamide- induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulin, neutrophil adhesion and indirect hemagglutination test. Hesperidin was administered orally at doses of 25, 50 and 100 mg/ kg p.o. Cyclophosphamide (30 mg/kg p.o.) was used as a standard immunosuppressant. Results: Hesperidin in all test doses demonstrated notable immunomodulatory responses in a sheep red blood cell challenge model. There was a refurbishment in the functioning of leucocytes in cyclophosphamide- treated rats and an increased clearance of carbon particles. The antibodytiter in the hemagglutination test showed increased levels of immunoglobulin. Discussion and Conclusion: The results of the present study indicate that hesperidin possesses sufficient potential for modulating immune activity by cellular and humoral mediated mechanisms.

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.