Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations

groupview

Abstract
Pharmacognosy Communications,2015,5,2,140-144.
Published:2nd Feb, 2015
Type:Research Article

Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations

Okey Alphonsus Ojiako1, Paul Chidoka Chikezie2

1Department of Biochemistry, Federal University of Technology, Owerri, Nigeria

2Department of Biochemistry, Imo State University, Owerri, Nigeria.

Abstract:

Background/Aim: The present study investigated alterations in blood Na+/K+ and Cl- levels of alloxan-induced hyperglycemic rats (HyGR) administered with single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Emilia coccinea, Hibiscus rosa sinensis and Asystasia gangetica. Materials and Methods: Serum electrolytes concentrations were measured using the ion selective electrode analyzer. Results: Serum Na+ concentration (SNC) of the untreated HyGR (DIAB group) was significantly (p<0.05) lower than that of the normal control rats (NORM group).However, HyGR administered with single herbal formulations (SHf) exhibited relatively higher SNC than that of the DIAB group (p< 0.05), which was within the range of 133.3±13.6 mMol/L–138.2±15.3 mMol/L; DIAB[Na+]=127.8±12.4 mMol/L. Serum K+ concentration (SKC) of the NORM group was significantly (p<0.05) higher than that of the DIAB group. Serum Cl- concentration (SCC) of the DIAB group was not significantly different (p>0.05) from those treated with SHf. Also, SCC of HyGR treated with triple herbal formulations (THf) was not significantly different (p>0.05) from HyGR treated with double herbal formulations (DHf), THf and quadruple herbal formulation (QHf). SNC exhibited a strong positive correlation with SCC (r=0.703231543). Conversely, SNC versus SKC (r=0.386096385) and SKC versus SCC (r=0.454718488) gave weak positive correlations. Conclusion: The present study showed that the various herbal formulations, in the present form, exhibited varied limited capabilities but substantial potentials to reversing altered blood electrolytes levels of HyGR within the 30- day treatment. Furthermore, definitive blood Na+<.Sup>/K+ and Cl- levels could be of diagnostic relevance in the course of management and treatment of DM.

Cite This Article

Vancouver Style :: Ojiako OAlphonsus, . Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations. Pharmacognosy Communications. 2015;5(2):140-144.  (443.33 KB)
MLA Style: Ojiako OAlphonsus, . Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations. Pharmacognosy Communications. 2015;5(2):140-144.  (443.33 KB)
CSE Style: Ojiako OAlphonsus, . Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations. Pharmacognosy Communications. 2015;5(2):140-144.  (443.33 KB)
APA Style: Ojiako OAlphonsus, . Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations. Pharmacognosy Communications. 2015;5(2):140-144.  (443.33 KB)

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.