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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    In vitro antifungal activity of oil of Cymbopogon citratus and citral alone and in combination with fluconazole against azole-resistant strains of Aspergillus fumigatus and Trichophyton rubrum

    wadmin2By wadmin2August 21, 2013Updated:August 12, 2021No Comments2 Mins Read
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    Mohd Sajjad Ahmad Khan* and Iqbal Ahmad
    Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh-202002, INDIA.

    Pharmacognosy Communications,2013,3,3,29-34.
    DOI:10.5530/pc.2013.3.6
    Published:August 2013
    Type:Research Article

    ABSTRACT

    Background: Curing of invasive and superficial mycoses by the available antifungal drugs is limiting because of the host toxicity and emergence of drug resistance in fungi. This has triggered search for anti-infective agents from natural products and alternative modes of antifungal therapy. Objective: The aim of this study was to evaluate in vitro antifungal activity of oil of Cymbopogon citratus and its major active compound citral alone and in combination with fluconazole against azole-resistant strains of Aspergillus spp and Trichophyton spp. Materials and Methods: The methodology adapted in this work included disc diffusion, broth macrodilution, time kill methods and checkerboard microtiter tests. Results: Test fungal strains exhibited higher levels of resistance to fluconazole and itraconazole (MIC range from 100 to 800 μg ml–1). Both the oil of C. citratus and citral exhibited promising antifungal activity (zone of inhibition from 24.66 to 42.00 mm) and killing potency against Aspergillus fumigatus MTCC2550 and Trichophyton rubrum IOA-9. Citral showed strongest synergy with fluconazole against A. fumigatus and T. rubrum by reducing the minimum inhibitory concentration of fluconazole up to eight-fold. Conclusion: The study has highlighted the broad spectrum antifungal activity of oil of C. citratus and citral and their synergy with fluconazole against azoleresistant strains of Aspergillus spp and Trichophyton spp.

    Keywords: Cymbopogon citratus, citral, azole-resistance, synergy.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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