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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Eupomatia laurina R. Br. fruit solvent extractions inhibit the growth of a panel of pathogenic bacteria

    wadmin2By wadmin2October 6, 2016Updated:August 6, 2021No Comments2 Mins Read
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    Krystal Bryant,a Ian Edwin Cock a,b*
    aSchool of Natural Sciences, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.
    bEnvironmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.

    Pharmacognosy Communications,2017,7,1,16-23.
    DOI:10.5530/pc.2017.1.3
    Published:October 2016
    Type:Original Article

    ABSTRACT

    Introduction: Eupomatia laurina are trees native to Australia and Papua New Guinea. The fruit of this species are consumed as a bushfood. Infusions and decoctions produced from leaves and bark have reputed antiseptic properties and were used traditionally to treat a variety of bacterial diseases. Despite this, E. laurina fruit solvent extractions have not been rigorously examined for antibacterial properties against many pathogens. Methods: The antimicrobial activity of E. laurina fruit solvent extractions was investigated by disc diffusion and growth time course assays against a panel of pathogenic bacteria. The growth inhibitory activity was quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous E. laurina fruit extracts inhibited the growth of a wide range of bacterial species. Growth of both gram positive and gram negative bacteria was inhibited by the E. laurina fruit extracts to approximately the same extent. With some noteable exceptions, the methanolic extracts were generally more potent than the aqueous extracts. The methanolic and aqueous E. laurina fruit extracts were particularly potent inhibitors of P. mirabilis growth, with MIC values as low as 83 μg/mL (aqueous extract against the P. mirabilis clinical isolate). The antibacterial activity of the methanolic E. laurina fruit extract was further investigated by growth time course assays which showed significant growth inhibition in cultures of K. pneumoniae and P. mirabilis within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusions: The lack of toxicity of the E. laurina fruit extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria partially validate the traditional usage of these species to treat bacterial diseases and indicate their potential in the development of antiseptic agents.

    Key words: Eupomatia laurina, Eupomatiaceae, Native guava, Copper laurel, Australian plants, Antibacterial activity, Medicinal plants.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
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    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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