Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Callistemon linearis Schrad. and J.C. Wendl. Extracts Inhibit the Growth of Gram-Positive Bacteria but have no Effect on Gram Negative Bacteria

    wadmin1By wadmin1April 1, 2019Updated:August 9, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Getmore Chikowe1, Lindiwe Mpala1, Ian Edwin Cock1,2

    1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA

    Pharmacognosy Communications,2019,9,2,39-46.
    DOI:10.5530/pc.2019.2.10
    Published: April 2019
    Type: Original Article

    ABSTRACT

    Introduction: The development of multi-antibiotic resistant strains of bacteria has necessitated the search for new effective antibacterial therapies. Many Callistemon spp. were used traditionally to treat pathogenic illness and are rich in terpenoids with reported antibacterial activity. Despite this, the antibacterial activity of C. linearis leaf extracts has not been extensively examined. Methods: The ability of C. linearis leaf extracts to inhibit the growth of gram-negative and gram-positive bacterial species was investigated by disc diffusion and growth time course assays. The growth inhibitory activity was further quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic and aqueous C. linearis leaf extracts were good inhibitors of the growth of gram-positive bacteria yet were completely ineffective against gram-negative bacteria. The methanolic extract was a particularly good inhibitor of B. cereus and S. pyogenes growth, with MIC values of 610 and 354μg/mL respectively. The aqueous extract was also a good inhibitor of these bacteria (MICs of 927 and 660μg/mL respectively). Whilst the extracts also inhibited the growth of S. aureus and S. epidermidis, the MIC values (in the range 1200-1500μg/mL) were indicative of moderate inhibitory activity. The methanolic extracts were further investigated by growth time course assays that showed significant growth inhibition within 1h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for the treatment of gram-positive bacterial infections. Conclusion: The lack of toxicity of the C. linearis leaf extracts and their growth inhibitory bioactivity against the gram-positive bacteria indicate their potential in the development of new antibiotic chemotherapies.

    Keywords:Antibacterial, Antibiotic resistant bacteria, Bacillus cereus, Bottlebrush trees, Myrtaceae, Rheumatic fever, Streptococcus pyogenes, Traditional medicine.

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up