The Janus Corner


Pharmacognosy Communications,2017,7,1,61-62.
Published:October 2016
Type:The Janus Corner

The Janus Corner

aSchool of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.
bEnvironmental Futures Centre, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.


Compound Kushen injection (CKI) is a traditional Chinese medicine (TCM) formulation composed of aqueous Sophorae flavescentis Aiton root and Smilax glabrae Roxb. rhizome extracts. It has traditionally been used as an anti-inflammatory drug. It also has antineoplastic activity and has been approved in China to treat several cancers. Despite its chemotherapeutic usage, the anticancer mechanism of CKI is yet to be fully elucidated. This may be due to the reductionist approach of many scientific studies, which are reliant on the isolation and screening of individual extract components. Whilst this is a viable approach for many medicines, it is not always effective for complex plant based medicines. TCM generally consists of mixtures of plants/extracts, combined to create a high potency drug. Often, when the individual components are tested in isolation, they have poor efficacy, whereas combinations of components may have additive or synergistic effects. A recent study from an Adelaide University group examined the anticancer mechanism of CKI, 2 making it one of the first studies to report molecular mechanisms for complex mixtures. The study utilised a systems biology approach, which monitors all measurable aspects of the system, rather than focussing on a single bioactivity or morphological change. The research team determined that CKI affected multiple pathways, with cell cycle regulation being particularly important. Furthermore CKI was also reported to induce apoptosis in MCF-7 cells via p53 independent mechanisms. Read more. . . .


Cite This Article

Vancouver Style :: .E.Cock I. The Janus Corner. Pharmacognosy Communications. 2017;7(1):61-62.  (321.02 KB)
MLA Style: .E.Cock I. The Janus Corner. Pharmacognosy Communications. 2017;7(1):61-62.  (321.02 KB)
CSE Style: .E.Cock I. The Janus Corner. Pharmacognosy Communications. 2017;7(1):61-62.  (321.02 KB)
APA Style: .E.Cock I. The Janus Corner. Pharmacognosy Communications. 2017;7(1):61-62.  (321.02 KB)

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