Wound Healing Efficacy of Mimusops Elengi L. Flowers in Albino Wistar Rats using Excision Wound Model


Pharmacognosy Communications,2016,6,2,72-79.
Published:January 2016
Type:Original Article

Wound Healing Efficacy of Mimusops Elengi L. Flowers in Albino Wistar Rats using Excision Wound Model

Sunita Shailajan*1 and Deepti Gurjar1

Herbal Research Lab, Ramnarain Ruia College, Matunga (E), Mumbai 400019, INDIA.


Introduction: Mimusops elengi L. (Sapotaceae), known as Bakul in Ayurveda, is an evergreen tree found throughout India. M. elengi flowers (MEF) are reported to possess immunomodulatory, hepatoprotective, skin whitening, anti-anxiety and wound healing activities which may be attributed to its phytochemical constituents including triterpenoids, alkaloids, phenolics, volatile oils, etc. Although the flowers have been traditionally used as a wound healing agent, there is a paucity of scientific data in support of its efficacy. Methods: An ethanolic extract of MEF was evaluated for its wound healing potential in male Albino Wistar rats using an excision wound model. The ethanolic extract of MEF was standardized in terms of its gallic acid content using a validated HPTLC technique. The antioxidant activity of MEF was also evaluated in vitro. The wound healing potential of the ethanolic extract of MEF was studied on the basis of wound contraction data, epithelialization period, the effect on biochemical parameters from the granulation tissue and histopathological observations. The results were compared with the traditional drug Jatyadi Taila (JT) and the modern drug Betadine (BTD). Results: Topical application of the standardized ethanolic extract of MEF on excision wounds caused a significantly faster reduction in the wound area as compared to JT and BTD. Similarly, it also showed the significant increase in the tissue hydroxyproline, hexosamine and protein biochemical parameters when compared with the untreated control. Conclusion: The findings of the present study provide data on wound healing and antioxidant potential of MEF and supports their traditional therapeutic claim. 

Cite This Article

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.