Evaluation of Protective Effect of Glycyrrhiza glabra L. Extract on Isoniazid-Rifampicin Induced Hepatocellular Damage in Rats

groupview

Abstract
Pharmacognosy Communications,2020,10,1,18-22.
Published:December 2019
Type:Original Article

Evaluation of Protective Effect of Glycyrrhiza glabra L. Extract on Isoniazid-Rifampicin Induced Hepatocellular Damage in Rats

Chanchala Haldkar, Anupam Jaiswal, Aditya Ganeshpurkar*, Nazneen Dubey

Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, INDIA.

Abstract:

Context: Haphazard use of drugs is one of the key reasons for progression of liver diseases. Drugs such as paracetamol, isoniazid, rifampicin etc. cause hepatotoxicity. There is currently no single synthetic drug which is effective for the treatment of such conditions. Drugs from natural sources have been used by humans since before written records. Thus, plants serve to be an important source to explore hepatoprotectives. Objective: The current study was designed to assess the hepatoprotective activity of Glycyrrhiza glabra extract. Materials and Methods: Glycyrrhiza glabra roots were dried in shade, powdered and extracted with ethanol and phytochemical screening was performed. The extract phenolic and flavonoids contents were estimated. Hepatoprotective studies were performed using isoniazid- rifampicin induced hepatotoxicity in rats. Results: Results of the phytochemical studies demonstrated that the extract was rich in flavonoids, glycosides and polyphenolics. The extract also demonstrated excellent hepatoprotective activity against isoniazid- rifampicin induced hepatotoxicity in rats. Discussion and Conclusion: Results of study demonstrate that ethanol extract of Glycyrrhiza glabra is potent source of phytochemicals that are responsible to demonstrate hepatoprotective activity.

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.