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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Antioxidant and Anticancer Activities of Ocimum basilicum L. cv. Dark Opal (Lamiaceae)

    wadmin2By wadmin2September 18, 2014Updated:August 10, 2021No Comments2 Mins Read
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    Mohammadi Ma,*, Majd Ab, Nejadsattari Ta and Hashemi Mc
    aDepartment of Plant Science, Faculty of Basic Sciences, Science and Research Campus, Islamic Azad University, Tehran, Iran.
    bDepartment of Biology, Faculty of Biological Sciences, Tehran North Branch, Islamic Azad University, Tehran, Iran.
    cDepartment of Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

    Pharmacognosy Communications,2014,4,4,48-58.
    DOI:10.5530/pc.2014.4.5
    Published:September 2014
    Type:Research Article

    ABSTRACT

    Background: Plants used in folk and traditional medicines have been accepted as therapeutic drug development in modern medicine. Although many studies have been focused on Lamiaceae family, few studies on medical effects of purple basil have been performed until now. Objective: Ocimum basilicum cv. dark opal was chosen for this study as it has been used in Persian traditional medicine and many Iranian dishes. It was considered important to determine the cytotoxicity effect and the reductive capacity of the purple basil oils and extracts, as this may indicate their potential as antioxidants. Materials and Methods: The reducing power activity of both essential oils of the leaves (before flowering) and the seeds and also methanolic extracts of roots and aerial parts (stem-leaf) (collected prior flowering), and flowers were determined by utilizing of FRAP. Also the MTT assay has been used in order to consider in vitro cytotoxicity of essential oils and extracts on cancerous cell line (MCF-7). Moreover, the extracts were analyzed by HPLC todetermine the levels of some phenolic compounds. Results: The purple basil extracts have more powerful antioxidant activity than the essential oils. The MCF-7 cell proliferation was significantly inhibited compared with the controls, and the oils were found to be more effective than the extracts. The phytochemical analysis of the extracts has led to the identification of 3 phenolic. Conclusion: Our study, partially validates the traditional use of this medicinal herb as complementary and alternative medicine.

    Keywords: Purple basil, antioxidant, MCF-7, HPLC.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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