Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Short Communication

    The Anti-Proliferative Properties of Australian Plants with High Antioxidant Capacities Against Cancer Cell Lines

    wadmin2By wadmin2September 18, 2014Updated:August 10, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Jamieson Na, J Sirdaartaa,b and I. E. Cocka,b*
    aSchool of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.
    bEnvironmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.

    Pharmacognosy Communications,2014,4,4,71-82.
    DOI:10.5530/pc.2014.4.8
    Published:September 2014
    Type:Short Communication

    ABSTRACT

    Introduction: High levels of antioxidant phytochemicals have been linked to the treatment and prevention of several cancers. Recent reports have identified a number of native Australian fruits as having high antioxidant capacities. Despite this, several of these species are yet to be tested for anticancer activity. Methods: Solvent extracts were prepared from high antioxidant native Australian plants and their antioxidant capacities were determined by the DPPH free radical scavenging assay. Antiproliferative activities against CaCo2 and HeLa cancer cells were determined by an MTS based cell proliferation assay. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic and aqueous extracts of all plant species displayed high antioxidant contents (equivalent to 16-95 mg of vitamin C per gram of plant material extracted). In contrast, the ethyl acetate extracts for all species had relatively low antioxidant contents (generally below 5 mg of vitamin C equivalents per gram of plant material extracted). The antioxidant contents correlated with the ability of the extracts to inhibit proliferation of CaCo2 and HeLa cancer cell lines.The high antioxidant methanolic and aqueous extracts of all species were potent inhibitors of cell proliferation, with IC50 values generally below 1000 μg/mL. The aqueous S. australe fruit extracts were particularly effective, with IC50 values of 27 and 172 μg/mL against CaCo2 and HeLa cells respectively. In contrast, the lower antioxidant content ethyl acetate extracts generally did not inhibit cancer cell proliferation. Indeed, exposure of the cancer cells to most of the ethyl acetate extracts induced potent cell proliferation.The methanolic and aqueous Syzygium extracts displayed significant toxicity in the Artemia franciscana bioassay, with LC50 values below 1000 μg/mL.All other extracts were nontoxic. Conclusion: The antiproliferative activity of the high antioxidant plant extracts against HeLa and CaCo2 cancer cell lines indicates their potential in the treatment and prevention of some cancers.

    Keywords: Australian native fruits, Syzygium, Davidson’s plum, quandong, antioxidant capacity, anticancer activity, antiproliferative activity, functional foods.

    Download PDF

    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up