Facebook Twitter Instagram
    Trending
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    • Medicinal Plant Images
    • Upcoming Events
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    Research Article

    Antiepileptic Activity of Whole Plant of Leucas Martinicensis

    September 18, 2014Updated:August 10, 20212 Mins Read

    R Ramalingam1*, B Bindu Madhavi1, P Shruthi1, A Ravinder Nath2 and M Nagulu1
    1Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Nalgonda, Telangana, India. 508004
    2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India. 500017

    Pharmacognosy Communications,2014,4,4,59-63.
    DOI:10.5530/pc.2014.4.6
    Published:September 2014
    Type:Research Article

    ABSTRACT

    Background: Leucas martinicensis (LM) is an herbal plant that has been used in folk medicine to treat malaria, kidney disorders, inflammation and rheumatism. Objective: The present study was aimed to investigate the antiepileptic activity of ethanolic extract of whole plant of LM against pentylenetetrazole (PTZ) induced seizures in mice. Methods: The extract was first examined by acute oral toxicity studies and then evaluated for antiepileptic activity against PTZ induced seizures. Diazepam was used as the standard drug. Antiepileptic activity was evaluated by observing various seizure activities such as onset of seizure, duration of seizure and intensity of seizure. Motor coordination effect was studied using rotarod. Depression was studied using the forced swim test. Oxidative stress was measured by estimating Malondialdehyde content in the brain at the end of experiments. Results: No abnormalities or toxic effects were observed in the animals during acute oral toxicity studies. The extract treated groups showed late on set of seizures, decreased duration and intensity of seizure when compared with vehicle treated group. The extract was determined to protect the animals from loss of motor coordination and depression. Following sacrifice, the Malondialdehyde content in the extract treated groups were found to be less thanin the vehicle treated group. Conclusion: From the results of our present study it can be concluded that, the ethanolic extract of whole plant of LM protected the animals from seizures and suppressed the oxidative stress induced by PTZ, without producing loss of motor coordination or depression.

    Keywords: Forced swim test, Malondialdehyde, Oxidative stress, Pentylenetetrazole, Rotarod test.

    Download PDF

    Related Posts

    Molecular Docking of some Neem Constituents with COX-2 and NOs: An in silico Study

    July 1, 2020

    Trachiyspirum ammi (L.) Sprague ex Turrill Seed Extracts Lack Antibacterial Activity

    July 1, 2020

    Traditional Medicinal Knowledge in India and Malaysia

    February 2, 2015
    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    Facebook Twitter Instagram Pinterest
    © 2023 Phcog.net. Designed by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up