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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Experimental Evaluation of the Hepatoprotective Effect of Butea monosperma Extract on Antitubercular Drugs Induced Hepatotoxicity

    wadmin2By wadmin2September 18, 2014Updated:August 10, 2021No Comments2 Mins Read
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    NishaSonkar, Priyanka Yadav, Divya Bansal1, Aditya Ganeshpurkar* and Nazneen Dubey
    Drug Discovery Laboratory, Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, M.P., INDIA.
    1Pharmaceutics Research Laboratory, Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, M.P., INDIA.

    Pharmacognosy Communications,2014,4,4,59-63.
    DOI:10.5530/pc.2014.4.6
    Published:September 2014
    Type:Research Article

    ABSTRACT

    Context: Haphazard use of drugs is one of the key reason for progression of liver diseases. Drugs such as paracetamol, isoniazid, rifampicin etc cause hepatotoxicity. However, there is currently no single synthetic drug which is effective for the treatment of such conditions. Drugs from natural sources have been used by humans from eternal era. Thus, plants serve to be an important source to explore hepatoprotectives. Objective: The current study was designed to assess the hepatoprotective activity of Butea monosperma extract. Materials and methods: Leaves of B. monosperma were dried in shade, powdered and extracted with ethanol and phytochemical screening was performed. The extract phenolic and flavonoids contents were estimated. The extract was also subjected to acute toxicity studies as per OECD guidelines. Hepatoprotective studies were performed using isoniazid- rifampicin induced hepatotoxicity in rats. Results: Results of the phytochemical tests and phytoanalytical studies demonstrated that the extract was rich in flavonoids, glycosides and polyphenolics. The extract also demonstrated excellent hepatoprotective activity against isoniazid- rifampicin induced hepatotoxicity in rats. Discussion and conclusion: Results of study demonstrate that ethanol extract of B. monosperma is potent source of phytochemicals that are responsible to demonstrate hepatoprotective activity.

    Keywords: liver, Butea monosperma, hepatoprotective, SGPT, SGOT, ALP.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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