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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Pharmacological Effects of Peganum Harmala L. Root Extract on Isolated Rat small Intestine

    wadmin2By wadmin2May 26, 2014Updated:August 9, 2021No Comments2 Mins Read
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    Shatarat A1, Abuhamdah S2, Al-Essa M3, Mohammed F4 and Al-Olimat S5

    1Dept. of Anatomy and Histology, Faculty of Medicine, The University of Jordan, Jordan.

    2Dept. of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Jordan.
    3Dept. of Physiology and Biochemistry, Faculty of Medicine, The University of Jordan, Jordan.
    4Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Jordan.
    First two authors contributed equally to this study.

    Pharmacognosy Communications,2014,4,3,56-61.
    DOI:10.5530/pc.2014.3.6
    Published:May 2014
    Type:Original Article

    ABSTRACT

    Background: Peganum harmala L. is a medicinal plant used in Jordan and in many countries in traditional medicine against several diseases, including gastrointestinal disorders. Objective: In this study, the effects of crude ethanolic root extract of P. harmala on the isolated smooth muscle of the rat jejunum intestine were investigated. Materials and Methods: The isolated organ bath method was adopted. The efficacy was recorded and analyzed by biological signal collection and analysis recording. Results: The ethanolic root extract inhibited the spontaneous contraction of rat jejunum and showed dose dependent inhibition of acetylcholine Ach (10–5 m) and potassium chloride KCl (60 mm), as well as inducing contractions of isolated rat jejunum. The extract also reduced barium chloride BaCl2 (5 mm) induced contractions of isolated rat jejunum dose-dependently. The inhibitions were statistically significant. Conclusion: These results indicated that the root extract of P. harmala possesses antispasmodic activity and justifies its use traditionally in alleviating gastrointestinal disorders.

    Keywords: Gastrointestinal, Antispasmodic, Spasmolytic, Zygophyllaceace, Peganum harmala L., Small intestine, Rats.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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