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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Protective Effects of Alstonia scholaris (L.) R.Br. Bark Extract against Oxidative Stress Induced By Hydrogen Peroxide

    wadmin2By wadmin2December 28, 2012Updated:August 12, 2021No Comments2 Mins Read
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    Anowar Hussain , Bhaskarjyoti Gogoi and Anand Ramteke*
    Cancer Genetics and Chemoprevention Research Group, Department of Molecular Biology andBiotechnology,Tezpur University, Tezpur, Assam, INDIA.

    Pharmacognosy Communications,2013,3,1,16-20.
    DOI:10.5530/pc.2013.1.5
    Published:December 2012
    Type:Research Article

    ABSTRACT 

    Objective: To evaluate the protective effects of bark extract of Alstonia scholaris (L.) R.Br. against oxidative stress induced by hydrogen peroxide (H2O2). Materials and Methods: Study was carried out in isolated lymphocytes cultured in vitro . Lymphocytes were treated with extract or extract + H2O2 and the level of reduced glutathione (GSH) and nitric oxide (NO) as well as the activity of lactate dehydrogenase (LDH) were measured. Results: Treatment of lymphocytes with bark extract modulated the levels of GSH and NO with decreased LDH activity. Pretreatment with bark extract also significantly increased the level of GSH in lymphocytes treated with 1% H 2O2 . But, the levels of NO and LDH activity were decreased for similar treatment condition. Conclusion: The present data suggests that the protective effects of bark extract may be via up regulation of GSH and down regulation of NO levels. The modulation of GSH levels in the lymphocytes might be due to the phytochemicals present in the hydro-alcoholic extract of Alstonia scholaris .

    Keywords: Alstonia scholaris , hydrogen peroxide , Lactate dehydrogenas , nitric oxide , reduced glutathione.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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