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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Letter

    Antifungal and Antibacterial Properties of Three Medicinal Plants from Malaysia

    wadmin2By wadmin2March 25, 2013Updated:August 10, 2021No Comments2 Mins Read
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    Gwee Pei Shing1, Chen Li Wen1, Tan Syu Wei1, Ong Hean Chooi2, Khoo Kong Soo3 and Sit Nam Weng1*
    1Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia.
    2Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
    3Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia.

    Pharmacognosy Communications,2013,3,2,75-81.
    DOI:10.5530/pc.2013.2.15
    Published:March 2013
    Type:Research Letter

    ABSTRACT

    Introduction: The increase of opportunistic fungal infections and the escalation of bacterial resistance have seriously reduced the efficacy of chemotherapeutic agents available. Thus the search for new antimicrobial agents from natural sources such as medicinal plants becomes necessary. Methods: The aerial parts of Diplazium esculentum and Sechium edule, and the fruits of Solanum muricatum were used, and extracted sequentially using hexane, chloroform, ethyl acetate, ethanol, methanol, and water. The extracts were then evaluated, in triplicate, against a panel of 12 medically-important microorganisms for microbiostatic and microbiocidal activities using colorimetric broth microdilution methods. Results: The total percentage yield obtained were 1.20%, 1.84% and 3.53% (w/w, based on fresh weight) for D. esculentum, S. edule and S. muricatum, respectively. All plant extracts showed antifungal activity with 66% and 49% of the bioassays demonstrating fungistatic and fungicidal activity, respectively. Two yeasts, Cryptococcus neoformans and Issatchenkia orientalis were found to be susceptible to all extracts. The lowest minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) was exhibited by the hexane extracts of S. edule and S. muricatum against C. neoformans, both with values of 0.08 mg/mL. In the antibacterial screening assays, 49% of the bioassays exhibited bacteriostatic activity while only 21% of them showed bactericidal activity. The lowest MIC and minimum bactericidal concentration (MBC) was recorded for the hexane extract of S. muricatum against Bacillus cereus and Klebsiella pneumoniae, both with values of 0.31 mg/mL. The susceptibility of bacteria towards the plant extracts evaluated was species-dependent, with the susceptibility indices ranging from 0% for Escherichia coli to 72% for Pseudomonas aeruginosa. Conclusions: The results from this study show that extracts from these plants have significant antimicrobial activity, which corroborates their use in traditional medicine.

    Keywords: Bacteriostatic, bactericidal, broth microdilution, extraction, fungistatic, fungicidal, Diplazium esculentum, Sechium edule, S. muricatum.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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