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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Hypoglycemic Properties of Ethanolic Extracts of Gongronema Latifolium, Aloe Perryi, Viscum Album and Allium Sativum Administered to Alloxan-induced Diabetic Albino Rats (Rattus norvegicus)

    wadmin2By wadmin2March 25, 2013Updated:August 12, 2021No Comments2 Mins Read
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    Ibegbulem CO1 and Chikezie PC2
    1Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
    2Department of Biochemistry, Imo State University, Owerri, Nigeria.

    Pharmacognosy Communications,2013,3,2,12-16.
    DOI:10.5530/pc.2013.2.4
    Published:March 2013
    Type:Research Article

    ABSTRACT

    Background: Plants offer a wide range of natural compounds of medicinal values to humans and domestic animals. Objective: The ethanolic extracts of Gongronema latifolium, Aloe perryi, Viscum album (leaves) and Allium sativum (bulb) were investigated for their phytochemical/biochemical constituents and hypoglycemic properties. Materials and Methods: Hypoglycemia was induced in rats by a single dose (140 mg/kg) of intra-peritoneal injection of alloxan monohydrate in citrate buffer (pH 4.5). Suspensions of the ethanolic extracts were administered by intraperitoneal injection at doses of 2 mg/kg every 16 h for 54 h. Collection of blood samples for estimation of fasting blood glucose (FBG) was carried out at regular time intervals of 0, 16, 32, 48 and 54 h, using the glucose oxidase method. Results: Phytochemical and biochemical screening showed the presence of saponins, tannins, flavonoids, proteins and carbohydrates in the four plant tissues under investigation. A. sativum and G. latifolium also tested positive for the presence of alkaloids. The capacities of the four ethanolic extracts to reduce FBG concentrations in treated rats at the 54 h were in the order: A. perryi > G. latifolium > A. sativum > V. album. Comparatively, at t = 16 h, FBG concentration of V. album treated rats was not significantly different (p > 0.05) from those of G. latifolium treated group. Likewise, FBG concentration of rats treated with V. album extract did not show a significant difference (p > 0.05) compared to the group administered with extract of A. sativum. Conclusion: The four plant extracts used in the present study exhibited approximately the same capacity to act as hypoglycemic agents in the treated rats and correlate with the therapeutic capacity of the standard drug, glimepiride.

    Keywords: Hypoglycemia, phytochemical, A. perryi, G. latifolium, A. sativum, V. album, glimepiride.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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