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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Letter

    In vitro antimicrobial activity screening of tropical medicinal plants used in Santo Domingo,Dominican Republic. Part I.

    wadmin2By wadmin2March 25, 2013Updated:August 10, 2021No Comments2 Mins Read
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    Cesar M. Lozano1,*, Manuel A. Vasquez-Tineo2, Maritza Ramirez2 and Francisco Jimenez3
    1Institute of Physical-Chemical Applied Research, School of Sciences, University of Turabo, PO BOX 3030, Gurabo, Puerto Rico, 00778 USA.
    2Instituto de Innovación en Biotecnología e Industria (IIBI), Santo Domingo, Dominican Republic.
    3Nacional Botanical Garden “Dr. Rafael M. Moscoso”, Santo Domingo, Dominican Republic.

    Pharmacognosy Communications,2013,3,2,64-69.
    DOI:10.5530/pc.2013.2.13
    Published:March 2013
    Type:Research Letter

    ABSTRACT

    Introduction: Very little is known on the uses of medicinal plants in the Caribbean island of Dominican Republic. There is a lack of scientific data supporting medicinal plant uses. The objective of the present study was to evaluate the antimicrobial activity of crude extracts of 50 medicinal plants collected from vendors at regional or municipal markets and that are used in the treatment of several types of infections in Dominican Republic. Methods: Ethanolic plant extracts were tested against five microorganisms species – Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomona aeruginosa, and Candida albicans using the disc diffusion method. Extracts were inoculated onto discs and placed on agar plates spread with microorganisms using sterile swabs. Following 24 hours of incubation at 37°C, the plates were analyzed and the zones of inhibition measured. Results and Discussion: Fourty-four of the plants tested showed inhibitory activity against one or more of the microorganisms at a 35 μg/mL extract concentration. Plants exhibiting the widest antimicrobial activity were Inga vera, Ruellia tuberosa, Calophyllum calaba, and Merremia dissecta, and were effective on at least three out the four of the bacteria tested. The test antibiotics Amikacin and Norfloxacin showed strong inhibitory activities against all bacteria but only low activity against Klebsiella pneumonia. Very few extracts showed antifungal activity against Candida albicans, however higher activity was found using Cardiospermum halicacabum extract. Conclusions: Several ethanolic extracts derived from plants used in traditional medicine in Dominican Republic possess significant antimicrobial activity against a variety of the tested microorganisms, although the mechanism(s) of action require further study.

    Keywords: Ethnomedicine, natural products, antibacterial, antimicrobial, Dominican Republic, tropical medicinal plants.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
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