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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Letter

    Antimicrobial activity of Pseudomonas secondary metabolites

    wadmin2By wadmin2August 21, 2013Updated:August 11, 2021No Comments2 Mins Read
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    Mezaache-Aichour S1*, Guechi A1, Zerroug MM1, Nicklin J2 and Strange RN2
    1Laboratory of Applied Microbiology, Faculty of Natural and Life Sciences, University Ferhat Abbas of Sétif, ALGERIA.
    2School of Biological and Chemical Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK.

    Pharmacognosy Communications,2013,3,3,39-44.
    DOI:10.5530/pc.2013.3.8
    Published on:August 2013
    Type:Research Letter

    ABSTRACT

    Introduction: Phenazines are nitrogen-containing heterocyclic molecules produced by fluorescent Pseudomonas. These compounds have broad-spectrum antibiotic properties including antimicrobial activity against phytopathogenic fungi and pathogenic bacteria. Several mechanisms of action have been proposed, including inhibition of DNA replication, uncoupling of electron, transport and energy production, and disruption of normal membrane functions resulting in the generation of toxic intracellular oxygen species. Methods: Production of antimicrobial metabolites in vitro was assayed in NBY supplemented with glucose to a final concentration of 2%. Results: Extracts of supernatants from liquid cultures completely inhibited phytopathogenic fungi when incorporated into agar culture at a rateof 20 and 40 μg/ml, this crude extracts was active against all tested fungi. In a disc assay, extracts equivalent to 20 μg gave zones of inhibition of 15 mm and 25 mm for the Gram positive bacteria Bacillus subtilis and Paracoccus paratrophus, respectively with disc diffusion technique. The purified extracts were analyzed by UV spectroscopy and GC/MS.

    Keywords: Antimicrobial activity, phenazines, secondary metabolites.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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