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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Cuminum cyminum L. fruits distillate ameliorates the high fat diet-induced obesity

    wadmin2By wadmin2December 2, 2013Updated:August 11, 2021No Comments2 Mins Read
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    Mohammad Rafiul Haque1*, Shahid Husain Ansari1 and Abul Kalam Najmi3
    1Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 62, INDIA.
    2Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nager, New Delhi 62, INDIA.

    Pharmacognosy Communications,2013,3,4,49-57.
    DOI:10.5530/pc.2013.4.7
    Published:December 2013
    Type:Research Article

    ABSTRACT

    Introduction: Cuminum cyminum L. (Fam. Apiaceae) is a widely consumed spice. It is a rich sources of essential oils and has been actively researched for its chemical composition and biological activities. Aims: The study aimed to investigate the antiobesity effects of Cuminum cyminum L. distillates (CD) in high-fat-diet-induced obese rats. Methods: Twenty four male rats were randomly assigned to one of four groups: normal diet (ND), high fat diet (HFD), HFD + CD and HFD + orlistat. The CD was administered orally 7.75 ml/kg/twice a day for 4 weeks. Results: The CDtreated group significantly (p < 0.001) decreased the body weight gain, fat-pad weights, serum and hepatic lipids levels, insulin, glucose, leptin and pancreatic lipase activity in HFD-induced obese rats. The histological analysis revealed that the CD-treated group showed a remarkable reduction of macro vesicular steatosis in hepatic tissues and a significantly decreased number of lipid droplets and size of adipocytes compared to the HFD group. Conclusions: These findings demonstrate that CD treatment has a protective effect against a high-fat-diet-induced obesity in rats through the decreased activity in lipogenesis, as well as the increase in fatty acid oxidation and reduced intestinal absorption of dietary fat.

    Keywords: Apiaceae, Cuminum cyminum, antiobesity, high-fat-diet, rats.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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