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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Inhibition of the Growth of a Panel of Pathogenic Bacteria by Kunzea flavescens C.T. White and W.D. Francis Solvent Extractions

    wadmin2By wadmin2September 6, 2017Updated:August 12, 2021No Comments2 Mins Read
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    Getmore Rumbudzai Chikowe,a Lindiwe Nomathemba Mpala,a Ian Edwin Cocka,b*
    aSchool of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.
    bEnvironmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.

    Pharmacognosy Communications,2017,7,3,121-128.
    DOI:10.5530/pc.2017.3.18
    Published: September 2017
    Type: Original Article

    ABSTRACT

    Introduction: Kunzea flavescens C.T.White & W.D.Francis is a shrub that is native to eastern Australia. Several Kunzea spp. have been used as traditional medicines against bacterial pathogens. Despite this, K. flavescens leaf extractions have not been rigorously examined for growth inhibitory properties against many bacterial pathogens. Methods: The antimicrobial activity of K. flavescens leaf solvent extractions was investigated by disc diffusion and growth time course assays against a panel of pathogenic bacteria. The growth inhibitory activity was quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic, aqueous and ethyl acetate K. flavescens leaf extracts inhibited the growth of a wide range of bacterial species. Growth of both gram positive and gram negative bacteria was inhibited by the K. flavescens leaf extracts, although a higher proportion of gram positive species were susceptible. The methanolic extract was generally more potent than the aqueous or ethyl acetate extracts against all susceptible bacteria. The methanolic K. flavescens leaf extract was a particularly potent inhibitor of P. mirabilis and K. pneumoniae growth, with MIC values of 393 and 481 μg/mL respectively. The antibacterial activity of the methanolic K. flavescens leaf extract was further investigated by growth time course assays which showed significant growth inhibition in cultures of K. pneumoniae and P. mirabilis within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for internal use as well as for topical uses. Conclusions: The lack of toxicity of the K. flavescens leaf extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria indicate their potential in the development of novel antiseptic agents.

    Key words: Kunzea flavescens, Myrtaceae, Autoimmune inflammatory disease, Rheumatoid arthritis, Ankylosing spondylitis, Terpenoid, Antibacterial activity, Medicinal plants.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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