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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Correlating the Anti – Aging Activity with the Bioactive Profile of Chlorella emersonii KJ725233; Its Toxicological Studies for a Potential use in Cosmeceuticals

    wadmin2By wadmin2November 9, 2017Updated:August 12, 2021No Comments2 Mins Read
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    Sneha Sunil Sawant, Varsha Kelkar Mane*
    Department of Biotechnology, University of Mumbai, Kalina, Mumbai, Maharashtra, INDIA.

    Pharmacognosy Communications,2017,7,4,152-157.
    DOI:10.5530/pc.2017.4.22
    Published: November 2017
    Type: Original Article

    ABSTRACT

    Background: Microalgae due to an array of its antioxidant, antimicrobial and anti-inflammatory bioactives have been changing the cosmeceutical market. One such bioactive power pack is Chlorella emersonii KJ725233, a novel, non-fastidious freshwater microalga with an inherently higher antioxidant potential. Objective: The present study evaluates its potential use as a cosmeceutical ingredient with arrays of biochemical assays, toxicity studies and GC-HRMS profiling. Materials and Methods: In vitro proteinase inhibition activity of the methanolic extract of C. emersonii KJ725233 was evaluated using SAAANA, sodium hyaluronate and bovine collagen as substrates respectively. The radical scavenging potential was determined by DPPH assay and was correlated to the total flavonoid content evaluated by aluminium trichloride method. The bioactive composition was evaluated by GC – HRMS analysis. Eye irritation potential and sulforhodamine B assay were carried out using 3T3 fibroblasts cells to ascertain its non-toxic nature. Results: The methanolic extract of C.emersonii KJ725233 exhibited a potent elastase inhibition of 92.04±2.27% at a concentration of 1000 μg/mL. This was qualitatively established by the presence of phytol, its isomer and other anti-inflammatory molecules as revealed by GC HRMS profile. Its radical scavenging potential with an IC50 of 5.398±0.138 mg/mL exhibited a correlation coefficient of 0.9977 with its total flavonoid content. Toxicological studies on 3T3 fibroblast cell lines revealed its non – toxic as well as non – eye irritant nature. Conclusion: Its potential anti-aging and antioxidant activity coupled with its non-toxicity thus puts this microalga in the spot light for use in cosmeceutical industry.

    Key words: Chlorella emersonii KJ725233, Anti-aging, Anti-oxidant, Antiinflammatory, Bioactives, Cosmeceuticals.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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