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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Evaluation of Two Culinary Plant Species for Anticholinesterase, Antioxidant and Cytotoxic Activity

    wadmin2By wadmin2January 9, 2018Updated:August 9, 2021No Comments2 Mins Read
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    Ravinder Kaur, Richa Shri*

    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, INDIA.

    Pharmacognosy Communications,2018,8,1,25-28.
    DOI:10.5530/pc.2018.1.5
    Published:January 2018
    Type:Original Article

    ABSTRACT

    Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that markedly affects the cognitive functions. Although drugs are available for symptomatic relief, complete cure is yet to be achieved. Herbals are being explored for their anti-Alzheimer potential and some are excellent obstructers for pathological hallmarks of the disease. In this context we have investigated anticholinesterase, antioxidant and cytotoxic potential of the two culinary plant species Allium cepa and Ocimum basilicum. Materials and Methods: Hydro-methanol extracts of both plants were prepared by maceration. The extracts were standardized with respect to phenolic and flavonoid content. DPPH radical scavenging and ferric reducing assays were employed for antioxidant evaluation. Anticholinesterase prospective was evaluated using Ellman method. The cytotoxic effect of extracts on C6 glioma cells was examined by MTT assay. Results: Both the plant extracts displayed significant antioxidant activity in DPPH assay (IC50 value of A. cepa 30.10±6.96 μg/ml and O. basilicum 38.67±1.72μg/ml). Reducing ability was comparatively high for A. cepa. In the Ellman assay, A. cepa was determined to be a good acetylcholinesterase inhibitor (IC50 value: 51.78±1.05 μg/ml). Both the extracts were found to be non-toxic in MTT assay below the concentration of 100 μg/ml. The A. cepa extract had higher phenolic and flavonoid content. Conclusion: A. cepa has strong antioxidant and acetylcholinesterase inhibitory effect and can be considered an excellent candidate for developing as a drug for management of AD.

    Key words: Allium cepa, Ocimum basilicum, Anti-Alzheimer.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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