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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Serum Lactate Dehydrogenase Activity and Visceral Organs and Body Weights of Diabetic Rats Administered Single and Combinatorial Herbal Formulations

    wadmin2By wadmin2January 9, 2018Updated:August 12, 2021No Comments2 Mins Read
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    Chiwendu Maureen Chikezie1, Okey Alphonsus Ojiako1, Adamma Angela Emejulu1, Paul Chidoka Chikezie2*
    1Department of Biochemistry, Federal University of Technology, Owerri, NIGERIA.
    2Department of Biochemistry, Imo State University, Owerri, NIGERIA.

    Pharmacognosy Communications,2018,8,1,37-42.
    DOI: 10.5530/pc.2018.1.8
    Published: January-2018
    Type: Original Article

    ABSTRACT

    Background and Aim: The present study evaluated serum lactate dehydrogenase (LDH) activity. Visceral organs and body weights were used as measures of the capacities of single and combinatorial herbal formulations of Acanthus montanus, Asystasia gangetica, Gongronema latifolium and Solanum melongenas to ameliorate systemic toxicity, visceral organs inflammation or necrosis and body tissues wasting in alloxan-induced diabetes mellitus (DM) rats. Materials and Methods: Alloxan-induced DM rats with fasting plasma glucose concentration (FPGC) > 5.71 mmol/L for 5 consecutive days were selected for the study. A total of 102 male Wistar rats were divided into seventeen (17) groups of six (6) rats each. Serum LDH activity and body weights and weights of visceral organs and were measured using standard methods. Results: Serum LDH activities of herbal treated rat groups varied within a relatively narrow range of 549.9 ± 12.10 – 500.6 ± 12.02 IU/L and were significantly lower (p < 0.05) than the untreated DM rat group. The body weights of the experimental rat groups after herbal treatment were significantly higher (p < 0.05) than their corresponding weights before herbal treatment. The ratios of liver weights to body weights were within the range of 0.0293 ± 1.4 x 10-3 – 0.0597 ± 2.3 x 10-3. The ratio of kidney weight to body weight of untreated DM rat group was 1.64 fold higher than that of normal rat group (p > 0.05). Conclusion: Overall, 200 mg/kg body weight double herbal formulations of A. gangetica + A. montanus and A. gangetica + G. latifolium offered the greatest therapeutic benefits to alloxan-induced DM rats, with respect to all diagnostic parameters considered in the present study.

    Key words: Body weights, Diabetes mellitus, Herbal formulations, Lactate dehydrogenase, Visceral organs.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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