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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Study of the Antioxidant Property and Xanthine Oxidase Inhibitory Activity of Various Extracts from the Algerian Medicinal Plant Paronychia argentea L.

    wadmin2By wadmin2January 9, 2018Updated:August 9, 2021No Comments2 Mins Read
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    Moufida Adjadj*, Meriem Djarmouni

    Department of Biochemistry, Faculty of Natural and Life Sciences, Laboratory of Applied Biochemistry, University Ferhat Abbas, Setif 1, ALGERIA.

    Pharmacognosy Communications,2018,8,1,49-53.
    DOI:10.5530/pc.2018.1.9
    Published:January 2018
    Type:Original Article

    ABSTRACT

    Introduction: Paronychia argentea L. is used in traditional medicine to treat various diseases in Algeria especially kidney stones. This study was focused on the antioxidant and xanthine oxidase inhibitory activities of these plant extracts. Methods: The different extracts were prepared using solvents of increasing polarity, and their total polyphenols and flavonoids contents were determined using spectrophotometric methods. The antioxidant activities of Paronychia argentea extracts (PAE) were assessed by their inhibitory effect on xanthine oxidase (XO) and their scavenger ability on superoxide radical (O2 •-) generated by this enzyme. Results: The analysis PAE showed that ethyl-acetate extract (EaE) has the highest concentration of total phenolics and flavonoids compared with the chloroform extract (ChE) and the crude extract (CE). Results revealed that all PAE were effective in both XO inhibiting and superoxide radical scavenging, with the following order for the two assays: ChE > EaE > CE. Conclusion: This study provided evidence that PAE had interesting antioxidant potential which was confirmed using two enzymatic methods. Therefore, this plant could be used to treat gout and lot of diseases, where inhibition of XO and scavenging of superoxide radical are necessary.

    Key words: Flavonoids, Oxidative stress, Paronychia argentea L, Superoxide anion radical, Traditional medicine, Xanthine oxidase.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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