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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Phytochemical Investigation, Isolation and Characterization of Coumarins from Aerial Parts and Roots of Tunisian Pituranthos chloranthus (Apiaceae)

    wadmin2By wadmin2July 31, 2015Updated:August 10, 2021No Comments2 Mins Read
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    Latifa Aloui1, Mohamed Kossentini1, Claude Geffroy-Rodier2, Jérôme Guillard2, Sami Zouari1
    1Laboratoire de Chimie Appliquée: Hétérocycle, Corps Gras et Polymères, Faculté des Sciences de Sfax, Tunisia.
    2Institut de Chimie des Milieux et Matériaux de Poitiers, IC2MP UMR CNRS 7285, 4 rue Michel Brunet, TSA 51106, 86073 Poitiers Cedex 9, France.

    Pharmacognosy Communications,2015,5,4,237-243.
    DOI:10.5530/pc.2015.4.4
    Published:July 2015
    Type:Original Article

    ABSTRACT

    Pituranthos chloranthus, commonly known in Arabic as ‘Aljen,’ is a small aromatic plant which grows spontaneously in North Africa and it is widespread in central and southern Tunisia. This paper is the first report of its kind on the isolation and characterization of certain coumarin derivatives from the extract of the roots and aerial parts of this plant. Background:Pituranthos chloranthus (Apiaceae) commonly known as ‘Aljen’ is an endemic Tunisian aromatic plant, largely used in folk medicine. This plant contains bioactive compounds, particularly coumarin derivatives. The objective of the present study was to isolate and characterize some bioactive phytochemical constituents from the extract of the aerial parts and roots of Pituranthos chloranthus. Methods: Different extracts were subjected to column chromatography and eluted with solvent mixtures of increasing polarity (petroleum ether, ethyl acetate and methanol) to isolate five pure Products. The structure of the isolated compound was established using spectroscopic methods (UV, 1H-NMR, 13C-NMR, DEPT, HMBC, HSQC, COSY), and HRMS. Results: Isoimperatorin, osthol and oxypeucedanin were isolated from the n-hexane and ethyl acetate extract of the aerial part of the plant. Bergapten and nodakenetin were isolated from the methanolic extract of the roots. Conclusion:Pituranthos chloranthus contains bergapten, isoimperatorin, nodakenetin, osthol and oxypeucedanin which may be responsible for various pharmacological activities of the plant.

    Keywords: Apiaceae, Bioactive compounds, oxypeucedanin, Pituranthos chloranthus.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
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    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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