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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Anticonvulsant and anxiolyic activities of ethyl acetate fraction of Cassia fistula Linn. pods in mice

    wadmin2By wadmin2December 12, 2014Updated:August 10, 2021No Comments2 Mins Read
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    Chinnasamy Kalaiyarasia, Kalivaradhan Karthikaa, Govindharaj Ragupathia.
    aDepartment of Pharmacology, PSG College of Pharmacy, Coimbatore, Tamilnadu, India.
    bDepartment of Pharmaceutical Analysis, The Erode College of Pharmacy, Erode, Tamilnadu, India.

    Pharmacognosy Communications,2015,5,1,76-82.
    DOI:10.5530/pc.2015.1.8
    Published:12 2014
    Type:Research Article

    ABSTRACT

    Context: Cassia fistula L. (Leguminacea) is used by Indian and Tanzanian traditional healers for treating various ailments related to the central nervous system. Aims: The present study aimed to evaluate the anticonvulsant and anxiolytic activity of the ethyl acetate fraction obtained from a hydroalcoholic extraction of Cassia fistula pods (EAFCF) and thereby to provide scientific validation for its traditional use. Methods: Preliminary phytochemical analysis and estimation of the flavonoid content of the ethyl acetate fraction was performed. Anticonvulsant activity was assessed by the subcutaneous pentylenetetrazole test (s.c. PTZ test). Anxiolytic activity was assessed by elevated plus maze (EPM) and open field tests (OFT). The sedative and motor toxicity was evaluated by a phenobarbitone induced sleep test and rotarod behavior respectively. Results: Photochemical analysis revealed the presence of a high flavanoid content in the ethyl acetate fraction. Treatment of EAFCF (50 and 100 mg/kg) significantly increased the latency to the onset of minimal clonic seizure and generalized tonic clonic seizure and animals were completely protected from death due to PTZ administration. Administration of EAFCF at the dose of 100 mg/kg markedly increased the open arm entries and time spent in open arm in EPM. In OFT, EAFCF increased the number of central squares crossed and time spent in the central compartment. EAFCF in the doses used in this experiment did not produce sedation or motor toxicity. Conclusion: The results obtained herein clearly indicate the anticonvulsant and anxiolytic activity of EAFCF which may be due to the high flavonoid content. These findings give the scientific support for common use of this plant for treating epilepsy and anxiety.

    Keywords: Pentylenetetrazole, elevated plus maze, thigmotaxic behaviour, flavonoid content estimation, Cassia fistula, neurobehavioral profile.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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