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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Inhibitory activity of high antioxidant Australian native fruits against the bacterial triggers of selected autoimmune diseases

    wadmin2By wadmin2December 12, 2014Updated:August 10, 2021No Comments2 Mins Read
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    A. Maen,b I. E. Cock,a,b*
    aSchool of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.
    bEnvironmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.

    Pharmacognosy Communications,2015,5,1,52-62.
    DOI:10.5530/pc.2015.1.5
    Published:12 2014
    Type:Research Article

     ABSTRACT

    Introduction: High antioxidant capacities have been linked to the treatment of rheumatic diseases and in the inhibition of microbial growth. Recent reports have identified several native Australian fruits with high antioxidant capacities. Despite this, several of these species are yet to be tested for the ability to inhibit the growth of the bacterial triggers of autoimmune inflammatory diseases. Methods: Solvent extracts prepared from selectedAustralian native fruits were analysed for antioxidant capacity by the DPPH free radical scavenging assay.Growth inhibitory activities against bacterial species associated with initiating rheumatoid arthritis and ankylosing spondylitiswere determined bydisc diffusion assay and quantified by MIC determination. Toxicity was determined by Artemia franciscana bioassay. Results: Methanolic extracts of all plant species displayed high antioxidant contents (equivalent to approximately 7-16 mg of vitamin C per gram of fruit extracted). Most aqueous extracts also contained relatively high antioxidant capacities. In contrast, the ethyl acetate, chloroform and hexane extracts for most species (except lemon aspen and bush tomato) had lower antioxidant contents (below 1.5 mg of vitamin C equivalents per gram of plant material extracted). Interestingly, the bacterial growth inhibitory activity of the extracts did not correlate with their antioxidant capacities. The fruit extracts with the highest antioxidant capacities (lemon aspen and desert lime methanolic extracts) had only low antibacterial activity, with MIC values generally >10,000 μg/ml against all bacterial species. In contrast, the Illawarra plum and desert lime ethyl acetate extracts, which had mid-range antioxidant capacities (1-6.5 mg ascorbic acid equivalents/g extracted), had potent bacterial growth inhibitory activity (200-400 μg/ml). The native tamarind ethyl acetate extract displayed low-moderate toxicity in the Artemia franciscana bioassay (LC50valuesbelow 1000 μg/mL).All other extracts were nontoxic. Conclusion: The lack of toxicity and inhibitory activity against microbial triggers of rheumatoid arthritis and ankylosing spondylitis by the fruit extracts indicates their potential in the treatment and prevention of these diseases.

    Keywords: Muntries, Illawarra plum, lemon aspen, native tamarind, desert lime, bush tomato, rheumatoid arthritis, ankylosing spondylitis.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
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