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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Blood Na+/K+ and Cl- Levels of Hyperglycemic Rats Administered with Traditional Herbal Formulations

    wadmin2By wadmin2February 2, 2015Updated:August 10, 2021No Comments2 Mins Read
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    Okey Alphonsus Ojiako1, Paul Chidoka Chikezie2
    1Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
    2Department of Biochemistry, Imo State University, Owerri, Nigeria.

    Pharmacognosy Communications,2015,5,2,140-144.
    DOI:10.5530/pc.2015.2.5
    Published:February 2015
    Type:Research Article

    ABSTRACT

    Background/Aim: The present study investigated alterations in blood Na+/K+ and Cl- levels of alloxan-induced hyperglycemic rats (HyGR) administered with single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Emilia coccinea, Hibiscus rosa sinensis and Asystasia gangetica. Materials and Methods: Serum electrolytes concentrations were measured using the ion selective electrode analyzer. Results: Serum Na+ concentration (SNC) of the untreated HyGR (DIAB group) was significantly (p<0.05) lower than that of the normal control rats (NORM group).However, HyGR administered with single herbal formulations (SHf) exhibited relatively higher SNC than that of the DIAB group (p< 0.05), which was within the range of 133.3±13.6 mMol/L–138.2±15.3 mMol/L; DIAB[Na+]=127.8±12.4 mMol/L. Serum K+ concentration (SKC) of the NORM group was significantly (p<0.05) higher than that of the DIAB group. Serum Cl- concentration (SCC) of the DIAB group was not significantly different (p>0.05) from those treated with SHf. Also, SCC of HyGR treated with triple herbal formulations (THf) was not significantly different (p>0.05) from HyGR treated with double herbal formulations (DHf), THf and quadruple herbal formulation (QHf). SNC exhibited a strong positive correlation with SCC (r=0.703231543). Conversely, SNC versus SKC (r=0.386096385) and SKC versus SCC (r=0.454718488) gave weak positive correlations. Conclusion: The present study showed that the various herbal formulations, in the present form, exhibited varied limited capabilities but substantial potentials to reversing altered blood electrolytes levels of HyGR within the 30- day treatment. Furthermore, definitive blood Na+/K+ and Cl- levels could be of diagnostic relevance in the course of management and treatment of DM.

    Keywords: Chloride, Electrolytes, Herbal formulation, Potassium, Sodium.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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