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Antimicrobial Activity of the Genus Galium L.


Pharmacognosy Communications,2016,6,1,42-47.
Published:December 2015
Type:Original Article

Antimicrobial Activity of the Genus Galium L.

Ilyina Tatyana Vasilevna1*, Goryachaya Olga Volodymyrivna1, Toryanik Erica Leonidivna2, Kulish Irina Aleksandrovna2, Kovaleva Alla Mihaylovna1

1Departament of Pharmacognosy, 4 Bluchera st., The National University of Pharmacy, Kharkiv, Ukraine, EUROPE.

2Department of Clinical Laboratory Diagnostics, 12 Melnikova st., The National University of Pharmacy, Kharkiv, Ukraine, EUROPE.


Introduction: The common use of Galium L. plants (family Rubiaceae Juss.) in Ukrainian folk medicine for treating infectious diseases became the basis for the study of antimicrobial activity of lipophilic complexes obtained from the Galium species. Materials and Methods: The samples of herbs of Galium verum, Galium salicifolium, Galium dasypodum, Galium aparine, Galium carpaticum and Galium pseudomollugo harvested at flowering stage became the objects of the present research. Lipophilic complexes have been obtained by the exhaustive extraction of herbal drugs with chloroform in the Soxhlet apparatus. The complexes have been used as 2% alcohol solutions in 96% ethyl alcohol. The study was conducted in vitro by the agar diffusion method. Standard strains of micro-organisms were used to assess the antimicrobial activity. Results: Staphylococcus aureus was most sensitive to the studied lipophilic complexes. Escherichia coli and Proteus vulgaris showed low sensitivity. Pseudomonas aeruginosa and Bacillus subtilis have shown moderate sensitivity. The highest activity against Candida albicans has been observed in complexes of Galium aparine, Galium dasypodum, Galium pseudomollugo. Conversly, Galium verum manifested no activity against Candida albicans. The minimum bactericidal and inhibitory concentrations were determined. The correlation between the content of individual groups of biologically active substances and the level of activity of the complexes was established. All complexes were non-toxic. Conclusion: The results obtained provided us the basis for further in-depth studies of antimicrobial and antifungal activity of the lipophilic complexes of the genus Galium L.

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Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

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Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
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