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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    The Antihypoxic and Sedative Activity of the Dry extract from Asperula odorata L.

    wadmin2By wadmin2July 31, 2015Updated:August 10, 2021No Comments2 Mins Read
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    Iurchenko Nataliia Sergeevna*, IlyinaTatyanaVasilevna, Kovaleva Alla Mihaylovna, Toryanik Erica Leonidivna and Kulish Irina Aleksandrovna
    Departament of Pharmacognosy, 4 Bluchera st., The National University of Pharmacy, Kharkiv, Ukraine.

    Pharmacognosy Communications,2015,5,4,233-236.
    DOI:10.5530/pc.2015.4.3
    Published:July 2015
    Type:Original Article

    ABSTRACT

    Introduction: Sweet Woodruff (Asperula odorata L.) is a perennial herb that is spread throughout the territory of Ukraine. This herb is widely used in folk medicine of Ukraine as a sedative medicine at neurosis, neurasthenia, hysteria, depression, applied locally at allergic rash, and it is also used at metritis and colpitis in homeopathy. Materials and methods: The air-dried herb of Asperula odoratawas degreased with chloroform and then treated with the mixture of ethyl acetate-alcohol (8:2) to obtain a dry extract. Sedative activity was studied in the “open field” test. The protective effect of dry extract against hypoxia-induced lethality in mice was evaluated by experimental model of as phyctic hypoxia. HPLC analysis was used to identify the phenolic compounds in the dry extract. Results: The dry extract at the dose of 100 mg/kg in the “open field” test caused a significant dose-dependent (p>0.05) decreasing of locomotor activity which has evidenced by potent sedative activity. The dry extract at the dose of 100 mg/kg showed a potent antihypoxic activity which has been confirmed by increasing mice lifetime by 34.8 % in conditions of model hypoxia. In the dry extract, 16 phenolic compounds have been identified and quantified. Conclusion: Our data have provided a rational base for the folkloric use of the dry extract from Sweet Woodruff as a sedative and antihypoxic drug.

    Keywords: Antihypoxic activity, dry extract, HPLC, Phenolic compounds, Sedative activity, Sweet woodruff.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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