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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Experimental Evaluation of Anthelmintic effect of Gallic Acid

    wadmin2By wadmin2February 2, 2015Updated:August 10, 2021No Comments2 Mins Read
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    Mohit Patel, Aditya Ganeshpurkar*, Divya Bansal, Nazneen Dubey
    Shri Ram Institute of Technology-Pharmacy, Jabalpur, M.P., India.

    Pharmacognosy Communications,2015,5,2,145-147.
    DOI:10.5530/pc.2015.2.6
    Published:February 2015
    Type:Research Article

    ABSTRACT

    Background: Helminth infestation is most prevalent infestations by parasites, which affects large part of world’s population. It is one of the leading causes of malnutrition among children. Gallic acid (3,4,5 trihydroxybenzoic acid), a plant polyphenol, is a naturally abundant gallotannin, which is found in vegetables, fruits, legumes and beverages. The present study was undertaken to explore anthelmintic activity of gallic acid. Materials and Methods: Five concentrations (25, 50 and 100 mg/ml) of gallic acid were studied in the anthelmintic bioassay to determine the paralysis time and death time in the worm Pheretima posthuma. Piperazine citrate was used as standard in the study. The results are expressed as mean ± standard error of mean. Experiments were always performed in triplicates. Results: Gallic acid exposure to worms caused a dose dependent paralysis and death. At lower concentration, (10 mg/ml) paralysis time was 29.27 ± 1.62 min and time for death was 52.11 ± 1.92 min. Increase in concentration of gallic acid (100 mg/ml) caused paralysis within 20 min (20.97 ± 1.93) and death was observed within first 30 min (30.11 ± 1.63) Conclusion: The study confirms the significant anthelmintic activities of gallic acid. However further studies on tape worms and other worms is needed to be undertaken.

    Keywords: Anthelmintic, Gallic acid, Piperazine citrate.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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