Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Antipsychotic and behavior effect of the ethanolic extract from the bark of Maytenus macrocarpa (Ruiz &Pav.) Briq.in mice

    wadmin2By wadmin2July 31, 2015Updated:August 10, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Claudia Zambrano Santoyo1,2a, Lucero Zúñiga Espinoza1,2,a, Rosario Zanabria Puente1,2a, Joshi Zegarra Sánchez1,2a, Nathaly Zaga Quispe1,2a, Carlos Pante Medina1,2,b and Alberto Salazar Granara1,2,c.
    1Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de Investigación de Medicina Tradicional y Farmacología.
    2Sociedad Científica de Estudiantes de Medicina de la Universidad de San Martin de Porres.
    aJunior researcher and medicine student.; bResearch technician in animal species ; cDoctor in Medicine and Physician.

    Pharmacognosy Communications,2015,5,4,244-249.
    DOI:10.5530/pc.2015.4.5
    Published:July 2015
    Type:Original Article

    ABSTRACT

    Introduction: Different studies indicate that Maytenus has many effects and that M. obtusifolia species has a central nervous system depressant effect. Objective: To determine antipsychotic and behavior modifying effect of the Maytenus macrocarpa (Ruiz &Pav.) Briq.ethanolic extract, using the forced swim test and Irwin test. Method: 77 albino mice were used, with an average weight of 25 g. They were split into 7 groups and they were administered with Maytenus macrocarpa of 200 mg/kg, 400 mg/kg, 600 mg/kg, 800 mg/kg, 1000 mg/kg, caffeine 32 mg/kg, diazepam 32 mg/kg, fluoxetine 30 mg/kg, haloperidol 5 mg/kg, distilled water (placebo) 0,1 ml/10 g, and a control group. The Irwin test was used to evaluate presence or absence of lethality, convulsions, Straub tail, sedation, excitement, abnormal gait, jumps, motor in coordination, abdominal writhes, piloerection, stereotypies, head twitches, scratching and breathing. The forced swim test was used to evaluate the antidepressant effects of each substance. Results: The highest immobility time was observed in Maytenus macrocarpa, compared with Haloperidol (p > 0.05) in the doses of 400 mg/kg, both of the substances having a Gaussian distribution. Irwin test for Maytenus macrocarpa of 200 mg/kg had sedation effect at minute 30; doses of 400 mg/kg at minutes 15 and 45, and doses of 600 mg/kg, 800 mg/kg and 1000 mg/kg at 15 minutes. Conclusion: Antipsychotic effects and behavior modifying effects were demonstrated in Maytenus macrocarpa (Ruiz &Pav.) Briq.ethanolic extract.

    Keywords: Antidepressive, Antipsychotic, haloperidol, Maytenus.

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up