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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Protective Effect of Trichosanthes Dioica Extract Against Gentamicin Induced Nephrotoxicity in Rats

    wadmin2By wadmin2December 1, 2015Updated:August 11, 2021No Comments2 Mins Read
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    Joy Ashish Solomon,1 Aditya Ganeshpurkar1*, Vikas Pandey,2 Divya Bansal,2 Nazneen Dubey1
    1Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, MP, INDIA.
    2Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, MP, INDIA.

    Pharmacognosy Communications,2016,6,1,23-27.
    DOI:10.5530/pc.2016.1.4
    Published: December 2015
    Type: Original Article

    ABSTRACT

    Introduction: Nephropathy is one of the progressive complications prevailed all around the world that is observed which arises due to detrimental effects of metabolites created due to various metabolic and physiological reactions. Gentamicin is one of the drug that may cause nephrotoxicity. Objectives: Phytoremedies are being considered as to play deterrent role in the treatment of disease. T. dioica is widely distributed in Asian subcontinent and consumed as food. The present work is aimed to study nephroprotective activity of T. dioica. Subjects and Methods: Dried T. dioica fruits were extracted with methanol and the extract was subjected to phytochemical analysis. Acute toxicity was determined as per OECD guidelines. Gentamicin (80 mg/Kg) was used to induce nephrotoxicity. The extract was given orally. Kidney weight was determined and estimation of blood urea nitrogen, serum creatinine, uric acid, catalase, superoxide dismutase, glutathione peroxidase, lipid peroxidation, urinary electrolytes was performed. Results and Discussion: Decrement in serum urea and creatinine along with reduction in uric acid was observed. Similarly, restoration of antioxidant enzymes and normalization of urinary electrolytes and kidney weight was observed. Observations from present study divulged that T. dioica, which is a good source of antioxidant phytochemicals, is accountable for nephroprotective activity.

    Key words: T. dioica, Nephroprotective, Histopathology, Uric acid, Creatinine, Urea nitrogen.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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