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Protective Effect of Trichosanthes Dioica Extract Against Gentamicin Induced Nephrotoxicity in Rats

Joy Ashish Solomon,1 Aditya Ganeshpurkar1*, Vikas Pandey,2 Divya Bansal,2 Nazneen Dubey1
1Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, MP, INDIA.
2Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, MP, INDIA.

Pharmacognosy Communications,2016,6,1,23-27.
DOI:10.5530/pc.2016.1.4
Published: December 2015
Type: Original Article

ABSTRACT

Introduction: Nephropathy is one of the progressive complications prevailed all around the world that is observed which arises due to detrimental effects of metabolites created due to various metabolic and physiological reactions. Gentamicin is one of the drug that may cause nephrotoxicity. Objectives: Phytoremedies are being considered as to play deterrent role in the treatment of disease. T. dioica is widely distributed in Asian subcontinent and consumed as food. The present work is aimed to study nephroprotective activity of T. dioica. Subjects and Methods: Dried T. dioica fruits were extracted with methanol and the extract was subjected to phytochemical analysis. Acute toxicity was determined as per OECD guidelines. Gentamicin (80 mg/Kg) was used to induce nephrotoxicity. The extract was given orally. Kidney weight was determined and estimation of blood urea nitrogen, serum creatinine, uric acid, catalase, superoxide dismutase, glutathione peroxidase, lipid peroxidation, urinary electrolytes was performed. Results and Discussion: Decrement in serum urea and creatinine along with reduction in uric acid was observed. Similarly, restoration of antioxidant enzymes and normalization of urinary electrolytes and kidney weight was observed. Observations from present study divulged that T. dioica, which is a good source of antioxidant phytochemicals, is accountable for nephroprotective activity.

Key words: T. dioica, Nephroprotective, Histopathology, Uric acid, Creatinine, Urea nitrogen.

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