Error message

Deprecated function: The each() function is deprecated. This message will be suppressed on further calls in theme_biblio_custom() (line 367 of /home/phcogcommn/

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens


Pharmacognosy Communications,2016,6,2,93-99.
Published:January 2016
Type:Original Article

Growth Inhibitory Activity of Selected High Antioxidant Australian Syzygium Species Against the Food Poisoning and Tissue Necrotic Pathogen Clostridium Perfringens

Mitchell Henry Wright,1 Cameron Jay Lee,1 Charmaine Estelle Pollock,1 Anthony Carlson Greene,1 Ian Edwin Cock,1,2*

1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.

2Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.


Introduction: Clostridium perfringens is a gram positive pathogen which is an etiological agent in Clostridial myonecrosis and enteritis necroticans. Unless promptly treated, C. perfringens infections may result in tissue necrosis and death. Syzygium australe (brush cherry) and Syzygium luehmannii (riberry) fruit and leaves have documented therapeutic properties as general antiseptic agents against an extensive panel of bacteria. Despite this, studies are yet to test the growth inhibitory activity of these species against C. perfringensMethods: S. australe and S. luehmannii fruit and leaf extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Clostridium perfringens. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: Methanolic and aqueous S. australe and S. luehmannii fruit and leaf extracts as well as the corresponding fruit ethyl acetate extracts, displayed growth inhibitory activity in the disc diffusion assay against C. perfringens. The aqueous and methanolic extracts were particularly potent growth inhibitors, each with MIC values substantially <500 µg/mL.TheS. australe fruit extracts were nontoxic in the Artemia franciscana bioassay (LC50 values <1000 µg/mL). All ethyl acetate extracts were also nontoxic. In contrast, the S. luehmannii aqueous and methanolic extracts (fruit and leaf), as well as the S. australe leaf extracts displayed substantial toxicity in the assay. Conclusion: The potent growth inhibitory bioactivity of the fruit and leaf aqueous and methanolic Syzygium spp. extracts against C. perfringens indicates their potentialas medicinal agents in the treatment and prevention of clostridial myonecrosis and enteritis necroticans. 

Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs.

Pharmacognosy Communications [Phcog Commn.] is a new quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the  publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.

The journal aims to cater the latest outstanding developments in the field of pharmacognosy and natural products and drug design covering but not limited to the following topics:

  • Pharmacognosy and pharmacognistic investigations
  • Research based ethnopharmacological evaluations
  • Biological evaluation of crude extracts, essential oils and pure isolates
  • Natural product discovery and evaluation
  • Mechanistic studies
  • Method and technique development and evaluation
  • Isolation, identification and structural elucidation of natural products
  • Synthesis and transformation studies

Distinctions:  The most widely read, cited, and known Pharmacognosy Communications and website is well browsed with all the articles published. More than 20,000 readers in nearly every country in the world each month

Aim and Scope | Editorial Board | Indexed & Abstracted | Instruction to Authors | Manuscript Submission & Charges

Subjects Covered : Natural Products, Pharmacognosy, Phytochemistry, Marine Pharmacognosy and Zoo Pharmacognosy
ISSN :2249-0159 (Print) ; 2249-0167 (Online) Frequency : Quarterly Rapid at a time publication (4 issues/year)

Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online  publication is 45 days.
Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.