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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Antibacterial Activity of Harpagophytum procumbens (Burch.) DC. ex Meisn. Root Extracts against Gastrointestinal Pathogens and Bacterial Triggers of Autoimmune Diseases

    Web AdminBy Web AdminDecember 24, 2021Updated:December 24, 2021No Comments2 Mins Read
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    Alysha Bromley1, Ian E Cock1,2,*

    1School of Environment and Science, Griffith University, Nathan, Queensland, AUSTRALIA.

    2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Nathan, Queensland, AUSTRALIA.
    DOI: 10.5530/pc.2022.1.4

    ABSTRACT

    Background: Recent increases in the numbers of antibiotic resistant bacteria and corresponding decreases in antimicrobial discovery have focussed drug discovery efforts towards plant based medicines. Harpagophytum procumbens has been used in southern African traditional medicine for a variety of conditions including inflammation, and to treat bacterial infections. Despite this, investigations of the antibacterial activity of H. procumbens root extracts have been relatively neglected. Materials and Methods: The antimicrobial activity of H. procumbens root extracts was assessed using disc diffusion and liquid dilution minimum inhibitory concentration (MIC) assays against gastrointestinal pathogens and bacterial triggers of some autoimmune diseases. The toxicity of the individual samples was assessed using the Artemia nauplii lethality assay (ALA) and an MTS HDF cell viability assay. Results: Harpagophytum procumbens root extracts displayed notable antibacterial activity against several bacterial triggers of autoimmune diseases, and against several gastrointestinal bacterial pathogens. The methanolic and aqueous extracts were particularly good inhibitors of Proteus spp. (MIC 125-313 μg/mL), K. pneumonia (MIC 313 μg/mL), P. aeruginosa (MIC 625 μg/mL) and S. pyogenes (MIC 313 μg/mL). Substantially higher MIC values were recorded against A. baylyi and the gastrointestinal bacteria. None of the extracts were toxic in the ALA or MTS assays, indicating their suitability for therapeutic use. Conclusion: The H. procumbens root extracts were effective inhibitors of the growth of several bacterial triggers of autoimmune inflammatory diseases and had noteworthy activity against some gastrointestinal bacteria. Isolation and identification of the bioactive compounds may be beneficial in the development of new antibiotic drugs.

    Key words: Devil’s claw, Pedaliaceae, Medicinal plants, Conventional antimicrobials, Synergy, Interaction, Toxicity.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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