Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Andrographis paniculata (Burm.f.) Nees Leaf Extracts Lack Antibacterial Activity against some Bacterial Triggers of Inflammatory Diseases and are Non-toxic in vitro

    Web AdminBy Web AdminOctober 12, 2022Updated:October 12, 2022No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Jason Batten, I E Cock1,2,*
    1School of Environment and Science, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.
    2Centre for Planetary Health and Food Security, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.
    DOI: 10.5530/pc.2022.4.28

    ABSTRACT

    Introduction: The recent development of extensively antibiotic resistant bacteria has necessitated the search for novel antibacterial compounds. An examination of aromatic plants and traditional medicines is an attractive option for drug discovery. Andrographis paniculata (Burm.f.) Nees is used in southern Asian traditional medicine for a variety of purposes and has been reported to have antibacterial activity against a limited panel of bacteria. Methods: The ability of A. paniculata leaf extracts to inhibit the growth of a panel of bacterial pathogens which can trigger some autoimmune diseases in genetically susceptible people was investigated by disc diffusion assays. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: Andrographis paniculata leaf solvent extracts of varying polarity were completely ineffective at inhibiting the growth of some bacterial triggers of autoimmune inflammatory diseases. The extracts were nontoxic in the Artemia nauplii bioassay following 24hr exposure. Conclusion: Andrographis paniculata leaf extracts were completely ineffective bacterial growth inhibitors against the tested pathogens. However, these extracts may have other therapeutic properties and testing against other bacterial pathogens, protozoa, viruses and tumour cells is required.

    Keywords: Acanthaceae, Andrographis, Green chiretta, Antibacterial activity, Antibiotic resistant bacteria, Medicinal plants, Toxicity

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up