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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Combination of Phytochemicals in the Management of Polycystic Ovarian Syndrome Induced in Rats

    Web AdminBy Web AdminOctober 12, 2022Updated:October 12, 2022No Comments2 Mins Read
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    Vimal Temkar1,*, Sasikumar Menon2
    1Department of Zoology, Ramnarain Ruia Autonomous College, Mumbai, Maharashtra, INDIA.
    2TDM Lab, Sion, Mumbai, Maharashtra, INDIA.
    DOI: 10.5530/pc.2022.4.29

    ABSTRACT

    Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous reproductive disorder and the most common endocrinopathy that leads to anovulatory infertility. PCOS is associated with wide spectrum of complications in various health aspects including anovulation, hyperandrogenism, hirsutism, infertility and menstrual disturbance. Metabolic dysfunctions like obesity, dyslipidemia, diabetes mellitus, cardiovascular risk and changes in psychological feature such as mood disorders and decreased quality of life are also associated with PCOS. Disruption in secretion rates and metabolism of androgens, estrogens and other reproductive hormones is the major characteristic of PCOS. Balancing the disrupted hormone levels is therefore an effective treatment strategy in managing PCOS. Materials and Methods : PCOS was induced in female Sprague Dawley rats with body weights between 180-200g by administrating oral doses of letrozole for 21 days. After PCOS induction, different combinations of mimosine, β-sitosterol and diosgenin along with clomiphene citrate were administered for 15 days. Body weight, food intake, water intake and cage side observations were recorded during the study. Serum testosterone, FSH, LH, estrogens and progesterone, oxidative enzymes and lipid profile were measured to determine the efficacy of treatments. Ovarian histopathological features were also examined by light microscopy. Results: Rats after letrozole induced PCOS showed significant aberrations in hormonal levels (p≤0.001, 0.01) compared with the normal control group indicating induction of PCOS. The treatment with combinations of phytochemicals was found to be effective in resolving and normalizing the disrupted levels of hormones and other biochemical parameters caused due to PCOS. Significant histological changes in ovarian histology after PCOS induction was found to have resolved among all treatment groups, indicating the ovarian recovery following therapy. Conclusion: Results indicate the effectiveness of treatment with a combination of bioactive phytochemicals for balancing reproductive hormone levels. The results suggest that abnormality in hormonal level and changes in ovarian histoarchitecture due to PCOS may be reversed with treatment regimen of administering bioactive phytochemicals as an adjunct with clomiphene citrate.

    Keywords: PCOS, Bioactive phytochemicals, Clomiphene citrate, Mimosa pudica L., β-sitosterol, Mimosine, Diosgenin.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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