Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Antibacterial Activity and Toxicity Profiles of Epilobium parviflorum (Schreb.) Schreb. Extracts and Conventional Antibiotics against Bacterial Triggers of Some Autoimmune Diseases

    Web AdminBy Web AdminJanuary 23, 2023Updated:March 28, 2023No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Jason Batten1, Ian E Cock1, 2,*

    1School of Environment and Science, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.

    2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.

    DOI: 10.5530/pc.2023.1.6

    ABSTRACT

    Background: Epilobium parviflorum (Schreb.) Schreb. has been used traditionally to treat prostate, bladder and kidney diseases, as well as inflammation. However, E. parviflorum extracts are yet to be tested for the ability to inhibit the growth of bacterial triggers of autoimmune diseases. Materials and Methods: Antimicrobial activity was assessed using disc diffusion and liquid dilution minimum inhibitory concentration (MIC) assays against a panel of bacterial triggers of some autoimmune diseases. Interactions between the E. parviflorum extracts and conventional antibiotics were studied and classified using the sum of the fractional inhibitory concentration (ΣFIC). Notable synergistic interactions were further examined across a range of ratios using isobologram analysis. The toxicity of the individual samples and the combinations was assessed using the Artemia lethality assay (ALA) assay. Results: Epilobium parviflorum extracts displayed notable antibacterial activity against the bacterial trigger of rheumatoid arthritis (P. mirabilis), but were ineffective against K. pneumoniae, A. baylyi, P. aeruginosa and S. pyogenes. The methanolic and ethyl acetate extracts were particularly good inhibitors of P. mirabilis growth, with MIC values of 484 and 623μg/mL recorded respectively. Furthermore, combining the extracts with conventional antibiotics resulted in significant potentiation of the inhibitory activity for some combinations. Interestingly, all combinations containing chloramphenicol or ciprofloxacin produced either synergistic or additive effects against P. mirabilis. None of the individual components (nor the combinations) were toxic in the ALA assay. Conclusion: The E. parviflorum methanolic and ethyl acetate extracts displayed clinically relevant antibacterial activity against P. mirabilis when tested alone. Furthermore, the methanolic and aqueous extracts potentiated the activity of chloramphenicol and ciprofloxacin in combination. The lack of toxicity of the extract and combinations indicates that E. parviflorum methanolic and aqueous extract and antibiotic combinations may provide leads in the development of new therapies to prevent and treat rheumatoid arthritis.

    Keywords: Medicinal plants, Rheumatoid arthritis, Ankylosing spondylitis, Multiple sclerosis, Conventional antimicrobials, Synergy, Drug interaction, Toxicity.

    Download
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up