Ian E Cock1,2,*
1School of Environment and Science, Nathan Campus, Griffith University, Brisbane, Queensland, AUSTRALIA.
2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.
A recent study from a Pohang University, Korea group has reported that the hydroflavone gossypeptin, which is found in relative abundance in Hibiscus sabdariffa L., has therapeutic effects in a 5XFAD Alzheimer’s Disease (AD) mouse model.1 That mouse strain possesses human APP and PSEN1 transgenes, which are linked to familial AD and are known to enhance β-amyloid protein accumulation in brain cells. Mice treated with gossypeptin displayed significantly decreased cognitive impairment similar to those caused by AD. The cognitive improvement was associated with substantially decreased in β-amyloid aggregates in brain cells. Furthermore, the authors demonstrated that gossypeptin prevented the activation of genes associated with chronic inflammation and facilitated β-amyloid clearance from microglial cells. Further studies are required to confirm the findings and to determine the bioavailability of gossypeptin. Read more…