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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Effects of Hamamelis virginiana L. Extracts on Pseudomonas aeruginosa Growth and Antagonism of Ciprofloxacin

    Web AdminBy Web AdminMay 5, 2023Updated:May 5, 2023No Comments2 Mins Read
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    Matthew J Cheesman1, Sean R Alcorn1, Ian E Cock2,3,*

    1School of Pharmacy and Medical Sciences, Gold Coast Campus, Griffith University, Gold Coast, AUSTRALIA.

    2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.

    3School of Environment and Science, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.

    DOI: 10.5530/pc.2023.2.14

    ABSTRACT

    Introduction: Pseudomonas aeruginosa is a Muti-Drug Resistant (MDR) pathogen that causes a myriad of infectious diseases. Limited evidence exists for antibacterial properties of extract preparations from the Virginian witch hazel (WH; Hamamelis virginiana L.; family: Hamamelidaceae) and their interactions with conventional antibiotics, especially against this significant pathogen. Materials and Methods: Five solvents of varying polarity were used to prepare WH extracts that were dried and resuspended in aqueous solution (1% DMSO) for testing in agar disc diffusion and liquid microdilution MIC assays. Results: The water extract showed mild (but statistically insignificant) P. aeruginosa growth inhibition, whilst the methanolic extract produced significant inhibition on agar and an MIC value in broth assays of 587 μg/mL. Extracts prepared with ethyl acetate, hexane and chloroform were inactive. Combinations of the active extracts with ciprofloxacin (the only antibiotic used in this study that was active against P. aeruginosa) produced an antagonistic effect on growth inhibition. Conclusion: WH extracted with polar solvents inhibit P. aeruginosa growth but counteract the activity of the antibiotic ciprofloxacin. Mechanisms of WH extract activity towards this pathogen, and their interaction(s) with ciprofloxacin, are discussed.

    Keywords: Witch hazel, Pseudomonas aeruginosa, Extracts, Antibacterial, Antagonism, Traditional medicine.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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