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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine

    Web AdminBy Web AdminJuly 20, 2023Updated:July 24, 2023No Comments2 Mins Read
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    Kris Herawan Timotius1,2,*, Susana Elya Sudrajat2,3, Ika Rahayu1,2

    1Department of Biochemistry, Faculty of Medicine and Health Sciences, Universitas Kristen Krida Wacana (UKRIDA), Jakarta, INDONESIA.

    2Research Center for Jamu and Herbal Medicine, Universitas Kristen Krida Wacana (UKRIDA), Jakarta, INDONESIA.

    3Department of Pharmacology, Faculty of Medicine and Health Sciences, Universitas Kristen Krida Wacana (UKRIDA), Jakarta, INDONESIA.

    DOI: 10.5530/pc.2023.3.21

    ABSTRACT

    Introduction: Pilis is a traditional Javanese transdermal herbal formula applied on the forehead to cure dizziness, hazy vision, eyestrain, and fever. So far, there are no scientific report on the bioactive compounds of the aqueous extract of pilis. This study aimed to identify the main bioactive compounds in the aqueous extract of pilis, either fresh-made or commercial pilis. Then, the bioactivities of the identified bioactive compounds were described based on the relevant literature studies. Materials and Methods: LC-MS was used to analyze the aqueous extracts of various pilis. Relevant information on their bioactivity is available from the works of the literature. Results: The identified main bioactive compounds in the aqueous extract of pilis were: undulatoside A, viscumneoside II, kaempferol, quercetin, genistein, and 7-hydroxy- 5,8-dimethoxyflavone. Most compounds were in glycosidic form. The fresh-made pilis was more abundant in the number of bioactive compounds than the commercial pilis. Their bioactivities include antioxidant, anti-inflammation, neuroprotective, anti-cancer, and anti-microbial activities. Conclusion: Aqueous extracts of pilis, particularly fresh-made pilis, are promising transdermal forehead formulas rich in particular bioactive compounds with healing capacities to cure encephalitis and dizziness.

    Keywords: Dizziness, Encephalitis, Mother after birth, Overhead, Transdermal.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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