Facebook Twitter Instagram
    Trending
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    • Medicinal Plant Images
    • Upcoming Events
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    The Janus Corner

    The Janus Corner

    July 20, 2023Updated:July 24, 20232 Mins Read

    Ian E Cock1,2,*

    1School of Environment and Science, Nathan Campus, Griffith University, Brisbane, Queensland, AUSTRALIA.

    2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.

    DOI: 10.5530/pc.2023.3.22

    ABSTRACT

    Duiakenchuto (DKT) is one of the most commonly used herbal remedies in Japanese Kampo medicine, particularly for digestive complaints.1,2 It is a poly-herbal preparation, which consists of Ginseng radix (commonly known as ginseng), Zanthyoxylum fructus (Japanese pepper) and Zingiberis siccatum rhizome (ginger), mixed with maltose powder. Despite its common usage, rigorous scientific evaluations of its effects are lacking. A research group from Yokohama City University, Japan recently published a study reporting substantial reductions in dextran sodium sulfate-induced colitis in a murine model, whilst maintaining a healthy gastrointestinal symbiotic microbiome (including Lactobacillaceae spp.).3 DKT also induced increases in colon levels of the bacteria-derived immunomodulatory compound propionate, as well as protecting the integrity of the colon muscoa. It exerted these effects by upregulating Fut2 (a fucosyltransferase gene), as well as Reg3g (an antimicrobial peptide gene). Notably, DKT also increased the levels of group 3 innate lymphoid cells (ILC3s), which were decreased in colitis. Taken together, these findings demonstrate that DKT reduces the effects of experimentally induced colitis, and downregulates colonic inflammation. Read more…

    Download PDF

    Related Posts

    Editorial

    July 20, 2023

    Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases

    July 20, 2023

    Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease

    July 20, 2023
    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    Facebook Twitter Instagram Pinterest
    © 2023 Phcog.net. Designed by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up