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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    The Janus Corner

    Rhododendron subarcticum Leaf Essential Oil is Effective against Drug-Resistant Plasmodium falciparum and may therefore be Useful for Malaria Prophylaxis

    Web AdminBy Web AdminNovember 10, 2023Updated:November 10, 2023No Comments1 Min Read
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    Ian E Cock1,2

    1School of Environment and Science, Nathan Campus, Griffith University, Brisbane, Queensland, AUSTRALIA.

    2Centre for Planetary Health and Food Security, Nathan Campus, Griffith University, Nathan, Brisbane, Queensland, AUSTRALIA.

    DOI: 10.5530/pc.2023.4.30

    ABSTRACT

    A Canadian research team recently published a study in ACS Omega reporting that an essential oil produced using Rhododendron subarcticum leaves was effective at inhibiting the growth of Plasmodium falciparium parasites (IC50 = 105nM).1 The parasite stain tested in that study was reported to be a drug-resistant strain, although the authors did not define which drugs the strain was resistant to. The authors of that study also examined the terpenoid compounds in the essential oil and reported ascaridole (67% relative abundance) and p-cymene (21% relative abundance) to be the major essential oil constituents. Furthermore, the authors reported that ascaridole contributed the anti-P. falciparum activity, with an IC50 of 147nM. Interestingly, as the activity of the essential oil was greater (lower IC50) than isolated ascaridole, it is likely that other components in the essential oil also contribute to this activity, either directly, or as potentiators of acraridole’s activity.  Read more…

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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