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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Pharmacokinetic and Pharmacodynamic Interaction of Curcumin with Glimepiride in Normal and Diabetic Rats

    wadmin1By wadmin1July 1, 2012Updated:August 9, 2021No Comments2 Mins Read
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    Thatipamula Sandya Rani,1 Samala Sujatha1 and Ciddi Veeresham1*

    1Department of Pharmacognosy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh-506009, India

    Pharmacognosy Communications,2012,2,3,14-21
    DOI: 10.5530/pc.2012.3.4
    Published:July 2012
    Type: Research Article

    ABSTRACT

    Introduction: Herbal antidiabetic preparations are often used as an add-on therapy in diabetes and such herbal preparations often contain curcumin. Hence, in the present investigation the effects of curcumin on the pharmacokinetics and pharmacodynamics of glimepiride in normal as well as diabetic rats was studied. Methods: Pharmacokinetic study group I rats were administered with glimepiride (1 mg/kg; p.o.) on 8th day of the study. Group II rats were pretreated with curcumin (80 mg/kg; p.o.) for 7 days and on 8th day with glimepiride (1 mg/kg) followed by curcumin. Blood samples were collected at different time intervals and serum samples were analyzed using Highperformance liquid chromatography (HPLC). For the pharmacodynamic study, curcumin alone or in combination with glimepiride was administered to diabetic rats for 28 days and various biochemical parameters were determined. Total antioxidant status was determined by using the DPPH assay. Results: In normal and diabetic rats the combination of glimepiride with curcumin increased all the pharmacokinetic parameters including Cmax, AUC0 to n, AUCtotal, t1/2 and MRT. It also decreased the clearance, Vd markedly as compared to control group. The combination of glimepiride with curcumin provides significant protection against the diabetes induced alterations in the biochemical parameters. In addition, the combination of glimepiride with curcumin also improved the total antioxidant status. Conclusion: The results revealed that combination of glimepiride with curcumin led to the enhancement of bioavailability of glimepiride by inhibiting the CYP2C9 enzyme, which suggested that curcumin might be beneficial as an adjuvant to glimepiride in a proper dose, in diabetic patients.

    Key words: curcumin, CYP2C9, glimepiride, pharmacodynamics, pharmacokinetics

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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