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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Aerial parts of Enicostemma littorale Blume serve as antipyretic and antacid: in vivo and in vitro evaluations

    wadmin1By wadmin1July 1, 2012Updated:August 7, 2021No Comments2 Mins Read
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    Machhindra C. Garad,1 Manoj A. Upadhya,1 Dadasaheb M. Kokare,1 Prakash R. Itankar1
    1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur- 440 033, India

    Pharmacognosy Communications,2012,2,3,42-45
    DOI: 10.5530/pc.2012.3.9
    Published:July 2012
    Type: Research Article

    ABSTRACT

    Introduction: Enicostemma littorale Blume (Gentianaceae) is traditionally used as medicine for the treatment of diabetes, fever, rheumatism, stomachache, dyspepsia, hernia, itching, insect poisoning and malaria. In the present study, we investigated the antipyretic activity using Swiss Albino mice and in vitro antacid activity of the aqueous extract of the aerial parts of this plant. Materials and Methods: The extract was screened for various essential phytoconstituents by qualitative phytochemical screening. The antipyretic activity was evaluated by lipopolysaccharide (LPS) induced pyrexia using mice as the animal model. The in vitro acid neutralising capacity was determined to evaluate the antacid potency of the extract as compared to standard antacid drugs. Results: Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, steroids, glycosides, saponins and flavonoids in the aerial parts of E. littorale. The extract significantly reduced the LPS elevated body temperature in mice at 100, 200, 300, and 400 mg/kg doses throughout the observation period of 5 hours. The extract showed optimum antipyretic activity at 200 mg/kg dose. The extract also showed the antacid potency comparable with standard antacid drugs. Conclusion: We suggest that the aqueous extract of the aerial parts of E. littorale might play an important role in the antipyretic and antacid like activities.

    Key Words: Enicostemma littorale Blume, Gentianaceae, lipopolysaccharide, antipyretic activity, in vitro antacid activity

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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