Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Research Letter

    Evaluation of Anxiolytic Activity of Stellaria media Linn. Extracts in Mice

    wadmin1By wadmin1July 1, 2012Updated:August 7, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Disha Arora, Anupam Sharma
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160 014, India

    Pharmacognosy Communications,2012,2,3,58-61.
    DOI:10.5530/pc.2012.3.12
    Published: July 2012
    Type: Research Letter

    ABSTRACT

    Background: Stellaria media Linn. (Caryophyllaceae) has been traditionally used for a variety of ailments such as inflammation, blood diseases, eczema and nerve diseases. The present study was designed to evaluate the anxiolytic activity of various extracts of S. media in mice using the widely used elevated plus-maze (EPM) model. Materials and Methods: Test mice were administered a variety of extracts viz. petroleum ether, chloroform, methanol and water at four different dose levels (50, 100, 200 or 400 mg/kg, po), and compared with the standard anxiolytic drug, diazepam (2 mg/kg, po). Anxiolytic activity was confirmed by using an actophotometer. The methanol extract was also subjected to phytochemical screening. Results: The methanol extract (100 mg/kg) exhibited significant anxiolytic activity as evidenced by an increase in both the time spent in the open arms and the number of open arm entries. This effect was comparable to that produced by diazepam. Significant increase in the locomotory behavior of mice by the methanol extract, further confirmed its anxiolytic activity. Phytochemical screening of the methanol extract showed the presence of flavonoids, triterpenoids, proteins, tannins, carbohydrates, fixed oils and fats. Conclusion: The results indicate that the anxiolytic activity of S. media resides in its methanol extract.

    Key words: anxiolytic, elevated plus-maze, locomotor activity, Stellaria media

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up