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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Immunomodulatory and anti-oxidant potential of Alpinia galanga Linn. rhizomes

    wadmin1By wadmin1July 1, 2012Updated:August 6, 2021No Comments2 Mins Read
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    Alok Pal Jain, Rajesh Singh Pawara, Santram Lodhia and Abhay K. Singhaia
    aDepartment of Pharmaceutical Sciences, Dr. H. S. Gour University, SAGAR (M.P.) INDIA-470003.

    Pharmacognosy Communications,2012,2,3,30-37
    DOI: 10.5530/pc.2012.3.7
    Published:July 2012
    Type: Research Article

    ABSTRACT

    Introduction: The plant Alpinia galanga Linn.(Zingiberaceae) is widely distributed in India. It is a perennial, aromatic and rhizomatous herb which is traditionally used as a carminative, stomachic, disinfectant, aphrodisiac and for the treatment of inflammation. The objective of present study is to evaluate the immunomodulatory and antioxidant effects of different extracts in a dose-dependent manner. Methods: Immunomodulatory activity was studied by examining T cell proliferation, splenocyte proliferation and by delayed type hypersensitivity reaction measurement. The antioxidant effect was observed by measuring lipid peroxidation (LPO), reduced glutathione (GSH) content and by determination of superoxide dismutase (SOD) and catalase (CAT) activities. Results: The flavonoid fraction of Alpinia galanga Linn. extract significantly stimulated (P <0.001) T cell proliferation and splenocyte proliferation in mice spleen at a dose of 100 mg/kg body weight of mice. The aqueous fraction had a lower stimulatory effect than the flavonoid fraction. The presence of quercetin in the flavonoid fraction was confirmed by chromatographic studies. The antioxidant level of the spleen cells also increased following treatment with the flavonoid fraction. Conclusion: In conclusion the flavonoid fraction of Alpinia galanga Linn. rhizomes have greater immunostimulating effects as well as antioxidant effects in mice.

    Key words: Alpinia galanga; galangal; immunomodulatory; antioxidant; flavonoid fraction; quercetin

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
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