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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Study of the composition of the goutweed flowers essential oil, its renal effects and influence on uric acid exchange

    wadmin1By wadmin1July 1, 2012Updated:August 7, 2021No Comments2 Mins Read
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    O.O. Koyro,1 O.V. Tovchiga,1 S. I. Stepanova,2 S. Yu. Shtrygol’1
    1Department of Pharmacology, National University of Pharmacy, 61002, Pushkinskaya Street 53, Kharkiv, Ukraine. 2Department of Chemistry of Natural Compounds, National University of Pharmacy, 61002, Pushkinskaya Street 53, Kharkiv, Ukraine.

    Pharmacognosy Communications,2012,2,2,46-49.
    DOI:10.5530/pc.2012.3.10
    Published: July 2012
    Type: Research Article

    ABSTRACT

    The composition of the goutweed flower essential oil from Kharkiv region (Ukraine) was studied using gas chromatography-mass spectrometry. Sesquiterpenes have been found to be the main group of the essential oil. The principal compounds contained in the oil were β-farnesene (43.94%), α-bergamoten (15.32%), (E, E)-α-farnesene (8.84%) and 1,5,9,9-tetramethyl-1,4,7-cycloundecatrien (5.51%). Diuretic and uricosuric activity of the goutweed flower essential oil in a dose of 1 ml/kg has been determined for the first time. It has been shown that the single dose increases creatinine, urea and uric excretion with the urine volume being unchanged. In the course of administration, a diuretic effect appears, creatinine excretion returns to the initial state while urea and uric acid excretion decreases. No significant differences between the effects of the aforesaid essential oil and the reference drug olimetin are observed. Thus, the essential oil may be involved in the diuretic and uricosuric activity of goutweed.

    Key words: Aegopodium podagraria L., goutweed, diuretic agents, essential oil, uricosuric agents, uric acid

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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